Cytotoxin 4 Antibody

Datasheet
Code CSB-PA355645LA01NFG
See More Details
Size US$299
Uniprot No. P01443
Immunogen Recombinant Naja atra Cytotoxin 4 protein (22-81AA)
Raised in Rabbit
Species Reactivity Naja atra
Tested Applications ELISA
Relevance Basic protein that bind to cell membrane and depolarizes cardiomyocytes. This cytotoxin also shows lytic activities, but 2-fold more important than that of CTX-A2. It binds to the integrin alpha-V/beta-3 with a moderate affinity. Inhibits protein kinase C. It may interact with sulfatides in the cell membrane, which induces pore formation and cell internalization and is responsible for cytotoxicity in cardiomyocytes. It also may target the mitochondrial membrane and induces mitochondrial swelling and fragmentation.
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Cytotoxin 4 (CTX-4M) (CTX4) (Cardiotoxin A4) (CTX A4) (Cardiotoxin analog IV) (CTX IV)
Immunogen Species Naja atra (Chinese cobra)
Protocols ELISA Protocol
Research Area Others
Target Names N/A
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Basic protein that bind to cell membrane and depolarizes cardiomyocytes. This cytotoxin also shows lytic activities, but 2-fold more important than that of CTX-A2. It binds to the integrin alpha-V/beta-3 with a moderate affinity. Inhibits protein kinase C. It may interact with sulfatides in the cell membrane, which induces pore formation and cell internalization and is responsible for cytotoxicity in cardiomyocytes. It also may target the mitochondrial membrane and induces mitochondrial swelling and fragmentation.
Subcellular Location Secreted, Target cell membrane
Protein Families Snake three-finger toxin family, Short-chain subfamily, Type IA cytotoxin sub-subfamily
Tissue Specificity Expressed by the venom gland.

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