DBR1 Antibody

Code CSB-PA890914LA01HU
Size US$166
  • Immunohistochemistry of paraffin-embedded human thyroid tissue using CSB-PA890914LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA890914LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) DBR1 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
DBR1 antibody; DBR1_HUMAN antibody; Debranching enzyme homolog 1 (S. cerevisiae) antibody; Lariat debranching enzyme antibody; RNA lariat debranching enzyme antibody
Raised in
Species Reactivity
Recombinant Human Lariat debranching enzyme protein (1-220AA)
Immunogen Species
Homo sapiens (Human)

The DBR1 Antibody (Product code: CSB-PA890914LA01HU) is Non-conjugated. For DBR1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA890914LB01HU DBR1 Antibody, HRP conjugated ELISA
FITC CSB-PA890914LC01HU DBR1 Antibody, FITC conjugated
Biotin CSB-PA890914LD01HU DBR1 Antibody, Biotin conjugated ELISA
Purification Method
>95%, Protein G purified
It differs from different batches. Please contact us to confirm it.
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Tested Applications
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover. It may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis.
Gene References into Functions
  1. findings support a new view of the early steps in HIV genome replication - they support a model in which lariat formation of viral genomic RNA is important for minus-strand transfer, with DBR1 being required to resolve the lariat to allow reverse transcription to proceed PMID: 28931690
  2. Transcriptomic sequencing confirmed the effect of hDBR1 on RNA splicing, and metabolite profiling supported the observation that neoplasm is triggered by a decrease in hDBR1 expression both in vitro and in vivo. PMID: 28504715
  3. saturation mutagenesis of DBR1 and Gal4 and show that the experimental phenotypes for over 80% of the mutations correlate well with predicted effects of mutations on protein stability and RNA binding affinity. PMID: 26797105
  4. Results of protein-protein interaction between human Dbr1 and factors found in the Intron Large complex identify Xab2 and a novel protein CWF19L1 as specific interactors of DBR1. PMID: 25671812
  5. Inhibition of DBR1 caused a significant reduction in the formation of intermediate and full-length HIV-1 cDNA. PMID: 24672043
  6. Dbr1 protein cleaves the 2'-5' phosphodiester bond of intron lariats, necessary for subsequent intron degradation that follows pre-mRNA splicing. PMID: 1850323

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Subcellular Location
Protein Families
Lariat debranching enzyme family
Database Links

HGNC: 15594

OMIM: 607024

KEGG: hsa:51163

STRING: 9606.ENSP00000260803

UniGene: Hs.477700

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