DCTN2 Antibody

Code CSB-PA002220
Size US$100
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  • Western Blot analysis of A549 cells using Dynactin 2 Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
DCTN2
Alternative Names
50 kD dynein associated polypeptide antibody; 50 kDa dynein associated polypeptide antibody; 50 kDa dynein-associated polypeptide antibody; DCTN-50 antibody; DCTN2 antibody; DCTN2_HUMAN antibody; DCTN50 antibody; dynactin 2 (p50) antibody; dynactin 2 antibody; dynactin complex 50 kD subunit antibody; Dynactin complex 50 kDa subunit antibody; Dynactin subunit 2 antibody; DYNAMITIN antibody; p50 dynamitin antibody; RBP50 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthesized peptide derived from the C-terminal region of Human Dynactin 2.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IHC, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:10000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development.
Gene References into Functions
  1. This is the first time a haplotype on chromosome 12 containing sequence variants in the genes DCTN2, DNAH10, LRIG3, and MYO1A has been linked to an inherited neuropathy in humans. PMID: 26517670
  2. dynamitin is involved in the regulation of Nav1.5 cell-surface density PMID: 25088759
  3. the determinants of p50/DM required for self-oligomerization of the protein and for interactions with other subunits of the dynactin complex PMID: 20463029
  4. Altered levels of Cep135 and p50 by RNAi and protein overexpression caused the release of endogenous partner molecules from centrosomes. PMID: 14983524
  5. the Sec23p component of the COPII complex directly interacts with the dynactin complex through the carboxy-terminal cargo-binding domain of p150(Glued). PMID: 15580264
  6. DCTN2 is required in the earliest stages of peroxisome biogenesis. PMID: 15813749
  7. study does not support a major role for DCTN2 overexpression in carcinogenesis PMID: 16369996
  8. Data show how dynamitin's different structural domains contribute to its ability to self-associate, interact with dynactin and assemble into a complex with its close binding partner, p24. PMID: 18182012
  9. The interaction between ZW10 and dynamitin showed that the N-terminal region of ZW10 is the major binding site for dynamitin and, like full-length ZW10, could move along microtubules to the centrosomal area in a dynein-dynactin-dependent manner. PMID: 18782227

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Subcellular Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Membrane; Peripheral membrane protein.
Protein Families
Dynactin subunit 2 family
Database Links

HGNC: 2712

OMIM: 607376

KEGG: hsa:10540

STRING: 9606.ENSP00000408910

UniGene: Hs.289123

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