DDX39A Antibody

Datasheet

Code	CSB-PA006620ESR2HU
Size	US$166
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Image	Western blot All lanes: ATP-dependent RNA helicase DDX39A antibody at 2μg/ml Lane 1: A431 whole cell lysate Lane 2: 293T whole cell lysate Lane 3: HepG2 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 50, 37, 31 kDa Observed band size: 50 kDa Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA006620ESR2HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA006620ESR2HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) DDX39A Polyclonal antibody

Uniprot No.

O00148

Target Names

DDX39A

Alternative Names

DDX39A antibody; DDX39 antibody; ATP-dependent RNA helicase DDX39A antibody; EC 3.6.4.13 antibody; DEAD box protein 39 antibody; Nuclear RNA helicase URH49 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human ATP-dependent RNA helicase DDX39A protein (178-427AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus.

Gene References into Functions

DDX39B and its paralog DDX39A regulate androgen receptor splice variant AR-V7 generation PMID: 28025139
DDX39A is a potential biomarker for unfavorable neuroblastoma PMID: 26469522
The protein levels of DDX39 were found to be higher in malignant pleural mesothelioma cell lines compared to normal pleural mesothelial cells. PMID: 23749908
Results suggest that DDX39 is a suppressor of invasion and loss of its function predicts disease progression in bladder cancers. PMID: 22494014
#NAME? PMID: 22119546
Requirement of DDX39 DEAD box RNA helicase for genome integrity and telomere protection PMID: 21388492
UAP56 and URH49 exhibit an intrinsic CRM1-independent nucleocytoplasmic shuttling PMID: 21799930
Mx proteins exert their antiviral activity against IAV by interfering with the function of the RNA helicases UAP56 and URH49 PMID: 21859714
Data show that the two closely related RNA helicases UAP56 and URH49 have evolved to form distinct mRNA export machineries, which regulate mitosis at different steps. PMID: 20573985
Using a UL69 viral mutant that is unable to bind UAP56 and URH49, the authors demonstrated that UL69's interaction with UAP56 or URH49 does not contribute to the growth phenotype associated with the UL69 deletion mutant. PMID: 20610707
Regulation of URH49 mRNA expression and comparison with the related UAP56 RNA helicase. PMID: 15047853
Reducing the expression of UAP56 and URH49 resulted in a reduction in reporter gene expression as well as cell death within 72 h suggest that both helicases have essential but largely overlapping functions in the processing and export of mammalian mRNAs. PMID: 16949217
CIP29 physically and functionally associates with DDX39, suggesting their cooperation in the RNA metabolism. PMID: 17196963
DDX39 is a novel RNA helicase capable of promoting cancer cell growth PMID: 17548965

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Subcellular Location

Nucleus. Cytoplasm. Note=Can translocate to the cytoplasm in the presence of MX1.

Protein Families

DEAD box helicase family, DECD subfamily

Tissue Specificity

Detected in testis, and at lower levels in brain, kidney, lung, thymus, spleen and salivary gland.

Database Links

HGNC: 17821

KEGG: hsa:10212

STRING: 9606.ENSP00000242776

UniGene: Hs.311609

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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