DEDD Antibody

Code CSB-PA006648ESR1HU
Size US$166
Order now
Image
  • Western blot
    All lanes: DEDD antibody at 0.56μg/ml
    Lane 1: Mouse lung tissue
    Lane 2: Mouse thymus tissue
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 37, 41 kDa
    Observed band size: 37 kDa

  • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA006648ESR1HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA006648ESR1HU at dilution of 1:100

Have Questions? Leave a Message or Start an on-line Chat

Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) DEDD Polyclonal antibody
Uniprot No.
Target Names
DEDD
Alternative Names
CASP8IP1 antibody; Death effector domain containing antibody; Death effector domain containing protein antibody; Death effector domain containing testicular molecule antibody; Death effector domain-containing protein antibody; Death effector domain-containing testicular molecule antibody; DEDD 1 antibody; dedD antibody; DEDD_HUMAN antibody; DEDD1 antibody; DEDPro 1 antibody; DEDPro1 antibody; DEFT antibody; FLDED 1 antibody; FLDED-1 antibody; FLDED1 antibody; KE 05 antibody; KE05 antibody; OTTHUMP00000031822 antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human Death effector domain-containing protein (1-318AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro.
Gene References into Functions
  1. LINC00472 contributed to the increase in lung adenocarcinoma cell apoptosis and the inhibition of proliferation via regulating miR-24-3p/ DEDD. PMID: 30175664
  2. DEDD protein role in cell proliferation and migration of bladder cancer PMID: 28000900
  3. Via direct interaction with the class III PI-3-kinase (PI3KC3)/Beclin1, DEDD activated autophagy and induced the degradation of Snail and Twist, two master regulators of EMT PMID: 22719072
  4. FAS-associated death domain (FADD)-DED-induced reactive oxygen species (ROS) generation is triggered by membrane localization of FADD-DED, which shifts the cells into a state that stimulates and fuels ROS and ultimately results in cell death. PMID: 20070122
  5. DEDD forms nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC PMID: 11965497
  6. DEDD and DEDD2 may be important mediators for death receptors and that they may target caspases to the nucleus. PMID: 12527898

Show More

Hide All

Subcellular Location
Cytoplasm. Nucleus, nucleolus.
Tissue Specificity
Widely expressed with highest levels in testis.
Database Links

HGNC: 2755

OMIM: 606841

KEGG: hsa:9191

STRING: 9606.ENSP00000356985

UniGene: Hs.744092

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1
webinars: DT3C facilitates antibody internalization X
Place an order now

I. Product details

*
*
*
*

II. Contact details

*
*

III. Ship To

*
*
*
*
*
*
*

IV. Bill To

*
*
*
*
*
*
*
*