DEF6 Antibody

1. this study identifies Def6 as a novel inhibitor of osteoclastogenesis in physiological and inflammatory conditions PMID: 28314855
2. DEF6 expression may serve as an independent prognostic factor, and interacted positively with p16 toward high tumor stage and shorter survival. PMID: 27488395
3. IBP was expressed ectopically in someoral squamous cell carcinoma samples and correlated significantly with tumor size, differentiation, clinical stage and distant metastases PMID: 23088770
4. DEF6, a novel substrate for the Tec kinase ITK, contains a glutamine-rich aggregation-prone region and forms cytoplasmic granules that co-localize with P-bodies. PMID: 22829599
5. Molecular cloning of IBP, a guanine nucleotide exchange factor, which is highly expressed in the immune system. PMID: 12651066
6. IBP is a novel guanine nucleotide exchange factor and is recruited to the immunological synapse by T cell receptor engagement PMID: 12923183
7. DEF6 not only activates Rho-family GTPases but also cooperates with activated Rac1 to exert its cellular function PMID: 17121847
8. level of expression correlates with the degree of malignancy in breast carcinoma tissues PMID: 19393345
9. Overexpression of the Interferon regulatory factor 4-binding protein is associated with Colorectal Carcinoma. PMID: 19679060
10. DEF6, a novel PH-DH-like domain protein, is an upstream activator of the Rho GTPases Rac1, Cdc42, and RhoA. PMID: 15023524

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HGNC: 2760

OMIM: 610094

KEGG: hsa:50619

STRING: 9606.ENSP00000319831

UniGene: Hs.15476