DENND2D Antibody

Code CSB-PA887987LA01HU
Size US$166
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  • Western blot
    All lanes: DENND2D antibody at 4µg/ml + MCF-7 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 54 kDa
    Observed band size: 54 kDa

  • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA887987LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) DENND2D Polyclonal antibody
Uniprot No.
Target Names
DENND2D
Alternative Names
2010308M01Rik antibody; AI451421 antibody; DEN2D_HUMAN antibody; DENN domain containing 2D antibody; DENN domain-containing protein 2D antibody; DENN/MADD domain containing 2D antibody; DENND2D antibody; FLJ22457 antibody; MGC6915 antibody; RGD1305120 antibody; RP5-1180E21.2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human DENN domain-containing protein 2D protein (1-233AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The DENND2D Antibody (Product code: CSB-PA887987LA01HU) is Non-conjugated. For DENND2D Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA887987LB01HU DENND2D Antibody, HRP conjugated ELISA
FITC CSB-PA887987LC01HU DENND2D Antibody, FITC conjugated
Biotin CSB-PA887987LD01HU DENND2D Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function
Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.
Gene References into Functions
  1. resulted in increased cell motility and invasive ability. Moreover, miR-1246 increased cell motility by directly targeting DENN/MADD Domain Containing 2D (DENND2D) PMID: 27929118
  2. Higher frequency of promoter hypermethylation of DENND2D is associated with gastric cancer. PMID: 24695972
  3. DENND2D is a candidate tumor suppressor gene that was inactivated by promoter hypermethylation in patients with esophageal squamous cell carcinoma and may serve as a novel biomarker of esophageal squamous cell carcinoma. PMID: 24317529
  4. DENND2D is a candidate tumor suppressor gene that is inactivated by promoter hypermethylation in patients with Hepatocellular carcinoma and may serve as a novel biomarker of early recurrence of Hepatocellular carcinoma . PMID: 24189587
  5. Our data show that DENND2D might function as a tumor suppressor-like gene, preventing survival and expansion of cells with genetic damage through apoptosis mechanism. Absence of DENND2D might play a permissive role, as an early event, in tumorigenesis. PMID: 23182661
  6. Mutations in DENND2D in melanoma by inhibition of nonsense-mediated mRNA decay. PMID: 18677770

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Subcellular Location
Cytoplasm.
Tissue Specificity
In bronchial mucosa, mainly expressed in ciliated and basal epithelial cells and weakly in alveolar cells (at protein level). Tends to be down-regulated in lung cancers, immortalized bronchial epithelial cell lines and precancerous lesions.
Database Links

HGNC: 26192

OMIM: 615111

KEGG: hsa:79961

STRING: 9606.ENSP00000350266

UniGene: Hs.557850

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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