DGKB Antibody

Code CSB-PA290951
Size US$297
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  • Western blot analysis of extracts from HuvEC cells, using DGKB antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) DGKB Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
90 kDa diacylglycerol kinase antibody; DAG kinase beta antibody; DAGK2 antibody; DGK antibody; DGK B antibody; DGK beta antibody; DGK-beta antibody; Dgkb antibody; DGKB_HUMAN antibody; Diacylglycerol kinase beta (90kD) antibody; Diacylglycerol kinase beta 90kDa antibody; Diacylglycerol kinase beta antibody; Diglyceride kinase beta antibody; KIAA0718 antibody
Raised in
Species Reactivity
Synthesized peptide derived from internal of Human DGKB.
Immunogen Species
Homo sapiens (Human)
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
It differs from different batches. Please contact us to confirm it.
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has a higher activity with long-chain diacylglycerols like 1,2-di-(9Z-octadecenoyl)-sn-glycerol compared to 1,2-didecanoyl-sn-glycerol. Specifically expressed in brain, it regulates neuron-specific morphological changes including neurite branching and neurite spine formation.; Does not associate with membranes but has a diacylglycerol kinase activity.
Gene References into Functions
  1. Association with the efficiency of hematopoietic stem cells (HSC) mobilization to PB were found in the SNPs of the DGKB gene involved in cell transport and SDF-1-induced migration ability and of the VCAM1 gene which is essential for HSC homing, suggesting that SNPs involved in cell migration ability might be partly involved in HSC mobilization to peripheral blood. PMID: 27839966
  2. in addition to kinase activity, plasma membrane localization via the C1 domain and basic amino acids at the C-terminus were indispensable for neurite induction by DGKbeta PMID: 24695318
  3. forced expression of diacylglycerol kinase beta abrogated DAG accumulation at the phagosome, leading to impaired respiratory burst. PMID: 23814057
  4. human diacylglycerol kinase beta gene can generate several enzyme isoforms, which can display different expression levels and subcellular localization but similar enzymatic activities in vitro. PMID: 11719522
  5. Includes the identification and expression profile of this gene (named as KIAA0718). PMID: 9872452
  6. Indicates that this protein can interact with keratin 31 and with protocadherin beta 5. PMID: 17353931

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Subcellular Location
Cell junction, synapse, postsynaptic cell membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Cytoplasm.; [Isoform 2]: Cytoplasm.
Protein Families
Eukaryotic diacylglycerol kinase family
Tissue Specificity
[Isoform 1]: Specifically expressed in brain but also detected in uterus. In adult brain, expressed in the amygdala, caudate nucleus, and hippocampus.; [Isoform 2]: More ubiquitously expressed but at lower level compared to isoform 1.
Database Links

HGNC: 2850

OMIM: 604070

KEGG: hsa:1607

STRING: 9606.ENSP00000382260

UniGene: Hs.567255

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