DHODH Antibody, HRP conjugated

Code CSB-PA006852LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) DHODH Polyclonal antibody
Uniprot No.
Target Names
DHODH
Alternative Names
DHOdehase antibody; Dhodh antibody; Dihydroorotate dehydrogenase (quinone) antibody; Dihydroorotate dehydrogenase antibody; Dihydroorotate dehydrogenase mitochondrial antibody; Dihydroorotate oxidase antibody; Human complement of yeast URA1 antibody; mitochondrial antibody; POADS antibody; PYRD_HUMAN antibody; URA1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Dihydroorotate dehydrogenase (quinone), mitochondrial protein (241-395AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
Gene References into Functions
  1. This case with grossly raised plasma DHO represents the first biochemical confirmation of functional DHODH deficiency. DHO was also easily detectable in dried plasma and blood spots. PMID: 27370710
  2. This is the first study to report on conformational changes of the HsDHODH N-terminal microdomain through a combination of CD and DEER spectroscopic techniques PMID: 26086954
  3. Considering that pyrimidine deficiency alone does not induce craniofacial dysmorphism, the DHODH mutations may contribute to the Miller syndrome in part through somehow altered mitochondrial function. PMID: 23216091
  4. Carriage of a six-marker DHODH haplotype was associated with a reduced treatment response (p = 0.008). PMID: 22966891
  5. The G202A and R346W mutation causes deficient protein stability, and the R135C mutation impairs the substrate-induced enzymatic activity, suggesting that impairment of DHODH activity is linked to the Miller syndrome phenotype. PMID: 22967083
  6. biallelic DHODH mutations in four unrelated families with typical clinical features of Miller syndrome. PMID: 22692683
  7. DHODH inhibition led to a marked decrease in melanoma growth both in vitro and in xenograft studies PMID: 21430780
  8. DHODH recessively causes Miller syndrome. PMID: 20220176
  9. required for N-(4-hydroxyphenyl)retinamide-induced reactive oxygen species production and apoptosis of cancer epithelial cells PMID: 20399851
  10. Data confirmed the presence of DHODH mutations in families with Miller syndrome. PMID: 19915526
  11. biophysical analysis of hydrogen bonding pathways in human dihydroorotate dehydrogenase PMID: 17004840
  12. Data provide new insights into the dynamic features of the DHODH reaction and suggest new approaches to the design of inhibitors against DHODH. PMID: 18672895
  13. DHODH polymorphism may be associated with incireased remiaaion in leflunomide treatment in rheumatoid arthritis patients. PMID: 19207032
  14. we report a new association of DHODH A40C polymorphism with leflunomide toxicity in patients with Rheumatoid Arthritis. PMID: 19605743

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Involvement in disease
Postaxial acrofacial dysostosis (POADS)
Subcellular Location
Mitochondrion inner membrane; Single-pass membrane protein.
Protein Families
Dihydroorotate dehydrogenase family, Type 2 subfamily
Database Links

HGNC: 2867

OMIM: 126064

KEGG: hsa:1723

STRING: 9606.ENSP00000219240

UniGene: Hs.654427

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