DHRS3 Antibody

Datasheet

Code	CSB-PA006860LA01HU
Size	US$166
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Image	Western blot All lanes: DHRS3 antibody at 0.8µg/ml Lane 1: A375 whole cell lysate Lane 2: Mouse liver tissue Lane 3: Mouse spleen tissue Lane 4: HL60 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 34, 19 kDa Observed band size: 19 kDa Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA006860LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA006860LA01HU at dilution of 1:100 Immunofluorescent analysis of A549 cells using CSB-PA006860LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) DHRS3 Polyclonal antibody

Uniprot No.

O75911

Target Names

DHRS3

Alternative Names

DHRS3; RDH17; SDR16C1; UNQ2424/PRO4983; Short-chain dehydrogenase/reductase 3; DD83.1; Retinal short-chain dehydrogenase/reductase 1; retSDR1; Retinol dehydrogenase 17; Short chain dehydrogenase/reductase family 16C member 1

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Short-chain dehydrogenase/reductase 3 protein (30-169AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The DHRS3 Antibody (Product code: CSB-PA006860LA01HU) is Non-conjugated. For DHRS3 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA006860LB01HU	DHRS3 Antibody, HRP conjugated	ELISA
FITC	CSB-PA006860LC01HU	DHRS3 Antibody, FITC conjugated
Biotin	CSB-PA006860LD01HU	DHRS3 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.

Gene References into Functions

Yap targets Dhrs3, to reduce retinoic acid synthesis and inhibit cardiac fibroblast differentiation during development. PMID: 29689192
Mouse Dhrs3 plays critical roles in the development of the heart by controlling the formation of retinoic acid. PMID: 29447006
The retinaldehyde reductase DHRS3 is essential for preventing the formation of excess retinoic acid during mouse embryonic development PMID: 24005908
we proposed that four newly identified peripheral blood mononuclear cells-derived genes( DHRS3, TTC38, SAP30BP and LPIN2 )could be integrated with previously reported rheumatoid arthritis (RA)-associated genes to monitor and/or diagnose RA. PMID: 28371410
the bifunctional nature of retinoid oxidoreductase complex provides the RA-based signaling system with robustness by safeguarding appropriate RA concentration despite naturally occurring fluctuations in RDH10 and DHRS3. PMID: 28232491
Data indicate that retinaldehyde reductase (DHRS3) requires retinol dehydrogenase 10 (RDH10) for full enzymatic activity and, in turn, activates RDH10. PMID: 24733397
p53-Inducible DHRS3 is an endoplasmic reticulum protein associated with lipid droplet accumulation. PMID: 21659514
The retSDR1 is identified as novel transcriptional target of the p53 family and not transactivated by EEC syndrome-specific mutations of TAp63gamma. PMID: 20543567
CST6, CXCL14, DHRS3, and SPP1 are regulated by BRAF signaling and may play a role in papillary thyroid carcinoma pathogenesis PMID: 18676742

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Subcellular Location

Membrane; Multi-pass membrane protein.

Protein Families

Short-chain dehydrogenases/reductases (SDR) family

Tissue Specificity

Widely expressed with highest levels found in heart, placenta, lung, liver, kidney, pancreas, thyroid, testis, stomach, trachea and spinal cord. Lower levels found in skeletal muscle, intestine and lymph node. No expression detected in brain. In the retin

Database Links

HGNC: 17693

OMIM: 612830

KEGG: hsa:9249

STRING: 9606.ENSP00000365397

UniGene: Hs.289347

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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