DLEC1 Antibody

Code CSB-PA006929GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
DLEC1
Alternative Names
DLEC1 antibody; DLC1Deleted in lung and esophageal cancer protein 1 antibody; Deleted in lung cancer protein 1 antibody; DLC-1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Human DLEC1
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Essential for spermatogenesis and male fertility. May play an important role in sperm head and tail formation. May act as a tumor suppressor by inhibiting cell proliferation.
Gene References into Functions
  1. We found no correlation between the DLEC1, TUSC4 and MLH1 gene expression and NSCLC patient characteristics (gender, age and smoking) or cancer histopathology. No significant differences in the gene expression among NSCLC subtypes indicate the weakness of DLEC1, TUSC4 and MLH1 expression analysis as potential differentiating markers of NSCLC subtypes in the Polish population. PMID: 28674222
  2. the expression levels of DLEC1 and ITGA9 were prominently decreased in lung tumor samples PMID: 27287342
  3. DLEC1 mediates tumor-suppressive activities through NF-kappaB signaling. PMID: 25648635
  4. DLEC1 methylation was not associated with the clinicopathological variables of gastric cancer. PMID: 25574068
  5. DLEC1 is down-regulated in head and neck squamous cell tumors and it's promoter methylation is not associated with the clinicopathological parameters. PMID: 25746324
  6. methylation-mediated silencing of DLEC1 plays an important role in multiple lymphomagenesis, and may serve as a non-invasive tumor marker for lymphoma diagnosis PMID: 23050586
  7. Repression of DLEC1 in squamous cell carcinoma tissues is associated with promoter hypermethylation. DLEC1 is downregulated in sinonasal squamous cell carcinoma and inverted papilloma and has a distinct mechanism. PMID: 22569009
  8. Epigenetic inactivation of DLEC1 was crucial in gastric and colorectal carcinogenesis. DLEC1 methylation in serum may be a promise biomarker for GAC and CRAC early diagnosis. PMID: 21443130
  9. results demonstrate that down-expression and promoter methylation of DLEC1 increased from normal tissues to premalignancies and then to malignancies. PMID: 20952247
  10. Frequent epigenetic inactivation of deleted in lung and esophageal cancer 1 gene by promoter methylation is associated with non-small-cell lung cancer. PMID: 20630829
  11. DLEC1 is often down-regulated by CpG methylation and shows tumor inhibitory function in renal cell carcinoma cells, indicating its role as a tumor suppressor PMID: 20639048
  12. DLEC1 expression levels were significantly lower in samples from patients who developed metastasis, local recurrence, or died of breast cancer when compared to those who were disease free for >10 years. PMID: 20530412
  13. DLEC1 suppresses the growth of ovarian cancer cells and its downregulation is closely associated with promoter hypermethylation and histone hypoacetylation PMID: 16756719
  14. Silencing of DLEC1 expression by promoter hypermethylation and histone deacetylation may be important in nasopharyngeal carcinoma tumorigenesis. PMID: 17099870
  15. DLEC1 is a candidate tumor suppressor gene that plays an important role in the development and progression of hepatocellular carcinoma. PMID: 18191269
  16. DLEC1 methylation was an independent marker of poor survival in patients with non-small cell lung carcinoma. PMID: 18594535
  17. DLEC1 underwent promoter methylation-associated silencing in colon and gastric tumour cell lines and primary tumours. PMID: 19156137

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Involvement in disease
Lung cancer (LNCR); Esophageal cancer (ESCR)
Subcellular Location
Cytoplasm.
Tissue Specificity
Expressed in all tissues examined. Expression is highest in prostate and testis.
Database Links

HGNC: 2899

OMIM: 133239

KEGG: hsa:9940

STRING: 9606.ENSP00000308597

UniGene: Hs.714499

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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