DME Antibody

Code CSB-PA839701LA01DOA
Size US$166
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Product Details

Full Product Name
Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) DME Polyclonal antibody
Uniprot No.
Target Names
DME
Alternative Names
DME antibody; At5g04560/At5g04570/At5g04580 antibody; T32M21.160/T32M21.170/T32M21.180Transcriptional activator DEMETER antibody; EC 3.2.2.- antibody; DNA glycosylase-related protein DME antibody
Raised in
Rabbit
Species Reactivity
Arabidopsis thaliana
Immunogen
Recombinant Arabidopsis thaliana Transcriptional activator DEMETER protein (1-320AA)
Immunogen Species
Arabidopsis thaliana (Mouse-ear cress)
Conjugate
Non-conjugated

The DME Antibody (Product code: CSB-PA839701LA01DOA) is Non-conjugated. For DME Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA839701LB01DOA DME Antibody, HRP conjugated ELISA
FITC CSB-PA839701LC01DOA DME Antibody, FITC conjugated
Biotin CSB-PA839701LD01DOA DME Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Transcriptional activator involved in gene imprinting. Catalyzes the release of 5-methylcytosine (5-meC) from DNA by a glycosylase/lyase mechanism. Allows the expression of the maternal copy of the imprinted MEA gene before fertilization, possibly by antagonizing or suppressing DNA methylation on target promoter. Probably acts by nicking the MEA promoter. Required for stable reproducible patterns of floral and vegetative development.
Gene References into Functions
  1. DME and ROS1 have a significant 5-hydroxymethylcytosine (5hmC) excision activity in vitro, although the study detected no 5hmC in Arabidopsis, suggesting that it is very unlikely for plants to utilize 5hmC as a DNA demethylation intermediate. PMID: 24661881
  2. Histone H1 is involved in DME-mediated DNA methylation and gene regulation at imprinted loci. PMID: 22519754
  3. DME is active and demethylates similar genes and transposons in the genomes of the vegetative and central cells in the male and female gametophytes PMID: 21518889
  4. Analyses indicate that AtLIG1 acts downstream of DME. The removal of methylated cytosine residues by DME involves the creation of DNA single-strand breaks and our results suggest that AtLIG1 repairs these breaks. PMID: 20023162
  5. Demethylation by DEMETER is necessary for genomic imprinting and defines the genomic methylation profile of Arabidopsis genes. PMID: 17409185
  6. Gene ontology analysis identified three molecular functions enriched in the DME-inducible RNA list: DNA or RNA binding, kinase activity, and transcription factor activity. PMID: 17964287
  7. control DNA methylation in Arabidopsis thaliana.[review] PMID: 18536342

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Subcellular Location
Nucleus.
Protein Families
DNA glycosylase family, DEMETER subfamily
Tissue Specificity
Mainly expressed in immature flower buds, then decreases as the flower matures. Expressed in the ovule carpels, but not expressed in pollen stamens. Expressed in developing and mature ovules (stages 12-14), then strongly decreases after fertilization.
Database Links

KEGG: ath:AT5G04560

STRING: 3702.AT5G04560.2

UniGene: At.33104

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