DMRT1 Antibody

1. DMRT1 might influence sex-specific patterns of childhood asthma, and its expression in testis tissue and lung macrophages suggests a potential involvement in hormone or immune cell regulation. PMID: 26906082
2. The results suggest a role of changes in DMRT1 dosage in non-obstructive azoospermia potentially also through a process of gene misregulation, even though DMRT1 deleterious variants seem to be rare. PMID: 26139570
3. The role of DMT1 in mitochondrial iron acquisition by immunofluorescence with mitochondrial markers in cells and isolated mitochondria, as well as flow cytometric quantification of DMT1-positive mitochondria from an inducible expression system. PMID: 25483589
4. These show that DMRT proteins use a unique binding interaction, inserting two adjacent antiparallel recognition helices into a widened DNA major groove to make base-specific contacts. PMID: 26005864
5. Point mutations of DMRT1 may be rarely associated with male infertility. PMID: 24934491
6. The combined results indicate that DMRT1 loss-of-function mutations are a risk factor and potential genetic cause of human spermatogenic failure PMID: 23555275
7. neither DMRT1 nor FGF9 abnormalities are frequently involved in dysgenetic male gonad development in patients with non-syndromic 46,XY disorder of sex development. PMID: 22939835
8. Meiosis signalling is dysregulated in carcinoma in situ (CIS) cells and that a key regulator of the mitosis-meiosis switch, DMRT1, is expressed in 'early-stage' CIS cells but is down-regulated with further invasive transformation. PMID: 23303528
9. The biological importance of the changes in expression of DMRT1 in Sertoli cells remains to be established, but it is consistent with DMRT1 reinforcing the inhibition of meiosis in the testis. PMID: 22899867
10. Findings continue to corroborate that genes influencing male germ cell development and differentiation have emerged as the major players in inherited TGCT susceptibility. PMID: 21551455
11. variants in or near BAK1, DMRT1, TERT-CLPTM1L, and KITLG predispose to familial and bilateral TGCT. PMID: 21617256
12. There is evidence that DMT1 expression and function respond rapidly to changes in dietary iron content PMID: 21462105
13. Chromosome 9p loss is the hallmark of squamous cell carcinoma, and DMRT1, DMRT3 and DOCK8 genes at 9p24.3 might be of interest for the study of the pathophysiology of SCC as potential targets for therapeutic measures. PMID: 20596660
14. Studies identified three new susceptibility loci DMRT1, TERT and ATF7IP associated with testicular germ cell cancer. PMID: 20543847
15. Analysis of germ cell tumors reveals gene expression changes correlated to DMRT1 levels. PMID: 20007774
16. Comparison of genomic and mRNA sequences show that DMRT1b and c result from exonization of intronic sequences, including the exonization of an Alu element. All 99 Alu elements are non-randomly distributed among the non-coding regions on both directions. PMID: 16617334

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HGNC: 2934

OMIM: 154230

KEGG: hsa:1761

STRING: 9606.ENSP00000371711

UniGene: Hs.98586