DNAI1 Antibody

Datasheet

Code	CSB-PA008835
Size	US$119
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q9UI46

Target Names

DNAI1

Alternative Names

Axonemal dynein intermediate chain 1 antibody; Axonemal dynein intermediate chain 2 antibody; CILD 1 antibody; CILD1 antibody; Cytoplasmic dynein 1 intermediate chain 1 antibody; Cytoplasmic dynein 1 intermediate chain 2 antibody; Cytoplasmic dynein intermediate chain 1 antibody; Cytoplasmic dynein intermediate chain 2 antibody; DH IC 1 antibody; DH IC 2 antibody; DIC1 antibody; DNAI 1 antibody; DNAI 2 antibody; DNAI1 antibody; DNAI1_HUMAN antibody; DNAI2 antibody; DNCI 2 antibody; DNCI1 antibody; DNCI2 antibody; DNCIC 1 antibody; DNCIC 2 antibody; DNCIC1 antibody; DNCIC2 antibody; Dynein axonemal intermediate chain 1 antibody; Dynein axonemal intermediate polypeptide 1 antibody; Dynein axonemal intermediate polypeptide 2 antibody; Dynein cytoplasmic intermediate polypeptide 1 antibody; Dynein cytoplasmic intermediate polypeptide 2 antibody; Dynein intermediate chain 1 axonemal antibody; Dynein intermediate chain 1 cytosolic antibody; Dynein intermediate chain 1; axonemal antibody; Dynein intermediate chain 2 axonemal antibody; Dynein intermediate chain 2 cytosolic antibody; Dynein intermediate chain DNAI1 antibody; IC74 antibody; ICS antibody; ICS1 antibody; Immotile cilia syndrome 1 antibody; MGC26204 antibody; PCD antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthesized peptide derived from the Internal region of Human Dynein IC1.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

WB, ELISA

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:20000

Protocols

Western Blotting(WB) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Part of the dynein complex of respiratory cilia.

Gene References into Functions

A novel mutation causing primary ciliary dyskinesia was found in Japanese patients. PMID: 28939216
The worldwide involvement of DNAI1 mutations in PCD pathogenesis in families not preselected for ODA defects ranges from 7 to 10%. PMID: 21143860
A total of 10% of patients with PCD are estimated to harbor mutations in DNAI1; most occur as a common founder IVS1+2_3insT or in exons 13, 16, and 17. PMID: 16858015
DNAI1 gene mutation is not a common cause of primary ciliary dyskinesia. PMID: 18434704
Two dynein genes, encoding ODA intermediate chain (DNAI1) and heavy chain (DNAH5), have been seen to be mutated in approximately 30-38% of the families PMID: 19300264

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Involvement in disease

Ciliary dyskinesia, primary, 1 (CILD1); Kartagener syndrome (KTGS)

Subcellular Location

Dynein axonemal particle. Cytoplasm, cytoskeleton, cilium axoneme.

Protein Families

Dynein intermediate chain family

Tissue Specificity

Expressed in respiratory ciliated cells (at protein level).

Database Links

HGNC: 2954

OMIM: 244400

KEGG: hsa:27019

STRING: 9606.ENSP00000242317

UniGene: Hs.112667

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Target Therapy

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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