DNAL1 Antibody

Datasheet

Code	CSB-PA002222
Size	US$100
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Image	Western Blot analysis of MCF7 cells using Dynein LC 1 Polyclonal Antibody
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Product Details
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Target Background

Product Details

Uniprot No.

Q4LDG9

Target Names

DNAL1

Alternative Names

axonemal antibody; Axonemal dynein light chain 1 antibody; Axonemal dynein light chain antibody; C14orf168 antibody; Chromosome 14 open reading frame 168 antibody; CILD16 antibody; DNAL 1 antibody; dnal1 antibody; DNAL1_HUMAN antibody; Dynein axonemal light chain 1 antibody; Dynein light chain 1 antibody; Dynein light chain 1 axonemal antibody; MGC12435 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthesized peptide derived from the Internal region of Human Dynein LC 1.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

WB, IHC, ELISA

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:100-1:300
ELISA	1:40000

Protocols

Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Part of the multisubunit axonemal ATPase complexes that generate the force for cilia motility and govern beat frequency. Component of the outer arm dynein (ODA). May be involved in a mechanosensory feedback mechanism controlling ODA activity based on external conformational cues by tethering the outer arm dynein heavy chain (DNAH5) to the microtubule within the axoneme. Important for ciliary function in the airways and for the function of the cilia that produce the nodal flow essential for the determination of the left-right asymmetry.

Gene References into Functions

DNAL1 and MAP4 may exert their functions in the HIV life cycle at reverse transcription, prior to nuclear translocation. PMID: 22018492
DNAL1 mutation could help to elucidate the interaction between the DNAL1 to dynein heavy chain and to tubulin. PMID: 21496787
identification of the human (DNAL1) ortholog of the Chlamydomonas LC1-gene; protein interaction studies demonstrated binding of DNAL1 and DNAH5; DNAL1 considered a candidate for primary ciliary dyskinesia PMID: 15845866

Involvement in disease

Ciliary dyskinesia, primary, 16 (CILD16)

Subcellular Location

Cytoplasm, cytoskeleton, cilium axoneme.

Protein Families

Dynein light chain LC1-type family

Tissue Specificity

Expressed in tissues carrying motile cilia such as respiratory epithelia, ependyma and testis.

Database Links

HGNC: 23247

OMIM: 610062

KEGG: hsa:83544

STRING: 9606.ENSP00000452037

UniGene: Hs.271270

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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