DND1 Antibody, FITC conjugated

1. Mechanistically, Dnd1 could bind to 3'-UTR of LATS2, the key kinase of Hippo pathway, thus elevating LATS2 mRNA stability and its expression, subsequently leading to phosphorylation of YAP and its cytoplasmic retention. PMID: 28593479
2. Dnd1 facilitates apoptosis by increasing the expression of Bim via its competitive combining with miR-221 in Bim-3'UTR. PMID: 28191469
3. RBM38 and DND1 are repressed in primary acute myeloid leukemia, neutrophil differentiation is dependent on increased expression of both proteins, and they have a role in regulating p21(CIP1) expression during acute promyelocytic leukemia differentiation PMID: 26740055
4. APOBEC3G inhibits DND1 function to regulate microRNA activity. PMID: 23890083
5. The increased sensitivity of transformed keratinocytes to miR-21's effects occurs in part through downregulation of the RNA-binding protein DND1 during the transformation process. PMID: 22614019
6. Results suggest that DND1 may impose another level of translational regulation to modulate expression of critical factors in ES cells. PMID: 21851623
7. We conclude that germline DND1 mutations are unlikely to contribute significantly to human testicular germ cell tumor susceptibility PMID: 20411342
8. Cloning of zebrafish dnd1 and identification of human DND1 by database analysis. PMID: 12932328
9. Unravels a novel role of Dnd1 in protecting certain mRNAs from miRNA-mediated repression. PMID: 18155131
10. MiR-24 up-regulation reduced the expression of RNA-binding protein dead end 1 (DND1). Knockdown of miR-24 led to enhanced expression of DND1. PMID: 20816961
11. Observational study of gene-disease association. (HuGE Navigator) PMID: 20411342
12. The variant, p. Glu86Ala, found in only one case of testiciular germ cell tumor, is within a known functional domain of DND1 and is highly conserved through evolution; mutations in DND1 make, at most, a very small contribution to TGCT susceptibility PMID: 18069663
13. Observational study of gene-disease association. (HuGE Navigator) PMID: 18069663

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HGNC: 23799

OMIM: 609385

KEGG: hsa:373863

STRING: 9606.ENSP00000445366

UniGene: Hs.591262