Name: DND1 Antibody, FITC conjugated
Brand: CUSABIO
SKU: CSB-PA809023LC01HU

Product Details

Full Product Name	Rabbit anti-Homo sapiens (Human) DND1 Polyclonal antibody
Uniprot No.	Q8IYX4
Target Names	DND1
Alternative Names	Dead end homolog 1 (zebrafish) antibody; dead end homolog 1 antibody; Dead end protein antibody; Dead end protein homolog 1 antibody; Dead end; zebrafish; homolog; 1 antibody; DND microRNA-mediated repression inhibitor 1 antibody; dnd1 antibody; DND1_HUMAN antibody; MGC34750 antibody; RBMS4 antibody; RNA binding motif single stranded interacting protein 4 antibody; RNA-binding motif antibody; single-stranded-interacting protein 4 antibody; Ter antibody
Raised in	Rabbit
Species Reactivity	Human
Immunogen	Recombinant Human Dead end protein homolog 1 protein (37-180AA)
Immunogen Species	Homo sapiens (Human)
Conjugate	FITC
Clonality	Polyclonal
Isotype	IgG
Purification Method	>95%, Protein G purified
Concentration	It differs from different batches. Please contact us to confirm it.
Buffer	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form	Liquid
Tested Applications	ELISA
Protocols	ELISA Protocol
Troubleshooting and FAQs	Antibody FAQs
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time	Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function	RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells (By similarity). Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs. Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3' untranslated region (3'-UTR) of several mRNAs. Does not bind to miRNAs. May play a role during primordial germ cell (PGC) survival (By similarity). However, does not seem to be essential for PGC migration (By similarity).
Gene References into Functions	Mechanistically, Dnd1 could bind to 3'-UTR of LATS2, the key kinase of Hippo pathway, thus elevating LATS2 mRNA stability and its expression, subsequently leading to phosphorylation of YAP and its cytoplasmic retention. PMID: 28593479 Dnd1 facilitates apoptosis by increasing the expression of Bim via its competitive combining with miR-221 in Bim-3'UTR. PMID: 28191469 RBM38 and DND1 are repressed in primary acute myeloid leukemia, neutrophil differentiation is dependent on increased expression of both proteins, and they have a role in regulating p21(CIP1) expression during acute promyelocytic leukemia differentiation PMID: 26740055 APOBEC3G inhibits DND1 function to regulate microRNA activity. PMID: 23890083 The increased sensitivity of transformed keratinocytes to miR-21's effects occurs in part through downregulation of the RNA-binding protein DND1 during the transformation process. PMID: 22614019 Results suggest that DND1 may impose another level of translational regulation to modulate expression of critical factors in ES cells. PMID: 21851623 We conclude that germline DND1 mutations are unlikely to contribute significantly to human testicular germ cell tumor susceptibility PMID: 20411342 Cloning of zebrafish dnd1 and identification of human DND1 by database analysis. PMID: 12932328 Unravels a novel role of Dnd1 in protecting certain mRNAs from miRNA-mediated repression. PMID: 18155131 MiR-24 up-regulation reduced the expression of RNA-binding protein dead end 1 (DND1). Knockdown of miR-24 led to enhanced expression of DND1. PMID: 20816961 Observational study of gene-disease association. (HuGE Navigator) PMID: 20411342 The variant, p. Glu86Ala, found in only one case of testiciular germ cell tumor, is within a known functional domain of DND1 and is highly conserved through evolution; mutations in DND1 make, at most, a very small contribution to TGCT susceptibility PMID: 18069663 Observational study of gene-disease association. (HuGE Navigator) PMID: 18069663 Show More Hide All
Subcellular Location	Nucleus, Cytoplasm
Database Links	HGNC: 23799 OMIM: 609385 KEGG: hsa:373863 STRING: 9606.ENSP00000445366 UniGene: Hs.591262

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Code	CSB-PA809023LC01HU
Size	US$299
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DND1 Antibody, FITC conjugated

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