Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) DND1 Polyclonal antibody

Uniprot No.

Q8IYX4

Target Names

DND1

Alternative Names

Dead end homolog 1 (zebrafish) antibody; dead end homolog 1 antibody; Dead end protein antibody; Dead end protein homolog 1 antibody; Dead end; zebrafish; homolog; 1 antibody; DND microRNA-mediated repression inhibitor 1 antibody; dnd1 antibody; DND1_HUMAN antibody; MGC34750 antibody; RBMS4 antibody; RNA binding motif single stranded interacting protein 4 antibody; RNA-binding motif antibody; single-stranded-interacting protein 4 antibody; Ter antibody

Raised in

Rabbit

Species Reactivity

Homo sapiens (Human)

Immunogen

Recombinant Homo sapiens (Human) DND1 protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Target Background

Function

RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells. Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs. Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3' untranslated region (3'-UTR) of several mRNAs. Does not bind to miRNAs. May play a role during primordial germ cell (PGC) survival. However, does not seem to be essential for PGC migration.

Gene References into Functions

Mechanistically, Dnd1 could bind to 3'-UTR of LATS2, the key kinase of Hippo pathway, thus elevating LATS2 mRNA stability and its expression, subsequently leading to phosphorylation of YAP and its cytoplasmic retention. PMID: 28593479
Dnd1 facilitates apoptosis by increasing the expression of Bim via its competitive combining with miR-221 in Bim-3'UTR. PMID: 28191469
RBM38 and DND1 are repressed in primary acute myeloid leukemia, neutrophil differentiation is dependent on increased expression of both proteins, and they have a role in regulating p21(CIP1) expression during acute promyelocytic leukemia differentiation PMID: 26740055
APOBEC3G inhibits DND1 function to regulate microRNA activity. PMID: 23890083
The increased sensitivity of transformed keratinocytes to miR-21's effects occurs in part through downregulation of the RNA-binding protein DND1 during the transformation process. PMID: 22614019
Results suggest that DND1 may impose another level of translational regulation to modulate expression of critical factors in ES cells. PMID: 21851623
We conclude that germline DND1 mutations are unlikely to contribute significantly to human testicular germ cell tumor susceptibility PMID: 20411342
Cloning of zebrafish dnd1 and identification of human DND1 by database analysis. PMID: 12932328
Unravels a novel role of Dnd1 in protecting certain mRNAs from miRNA-mediated repression. PMID: 18155131
MiR-24 up-regulation reduced the expression of RNA-binding protein dead end 1 (DND1). Knockdown of miR-24 led to enhanced expression of DND1. PMID: 20816961
Observational study of gene-disease association. (HuGE Navigator) PMID: 20411342
The variant, p. Glu86Ala, found in only one case of testiciular germ cell tumor, is within a known functional domain of DND1 and is highly conserved through evolution; mutations in DND1 make, at most, a very small contribution to TGCT susceptibility PMID: 18069663
Observational study of gene-disease association. (HuGE Navigator) PMID: 18069663

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Subcellular Location

Nucleus. Cytoplasm.

Database Links

HGNC: 23799

OMIM: 609385

KEGG: hsa:373863

STRING: 9606.ENSP00000445366

UniGene: Hs.591262

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DND1 Antibody

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Target Background