DND1 Antibody

Datasheet

Code	CSB-PA809023LA01HU
Size	US$166
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Image	Immunofluorescence staining of Hela cells with CSB-PA809023LA01HU at 1:233, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) DND1 Polyclonal antibody

Uniprot No.

Q8IYX4

Target Names

DND1

Alternative Names

Dead end homolog 1 (zebrafish) antibody; dead end homolog 1 antibody; Dead end protein antibody; Dead end protein homolog 1 antibody; Dead end; zebrafish; homolog; 1 antibody; DND microRNA-mediated repression inhibitor 1 antibody; dnd1 antibody; DND1_HUMAN antibody; MGC34750 antibody; RBMS4 antibody; RNA binding motif single stranded interacting protein 4 antibody; RNA-binding motif antibody; single-stranded-interacting protein 4 antibody; Ter antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Dead end protein homolog 1 protein (37-180AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The DND1 Antibody (Product code: CSB-PA809023LA01HU) is Non-conjugated. For DND1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA809023LB01HU	DND1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA809023LC01HU	DND1 Antibody, FITC conjugated
Biotin	CSB-PA809023LD01HU	DND1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IF

Recommended Dilution

Application	Recommended Dilution
IF	1:200-1:500

Protocols

ELISA Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells. Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs. Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3' untranslated region (3'-UTR) of several mRNAs. Does not bind to miRNAs. May play a role during primordial germ cell (PGC) survival. However, does not seem to be essential for PGC migration.

Gene References into Functions

Mechanistically, Dnd1 could bind to 3'-UTR of LATS2, the key kinase of Hippo pathway, thus elevating LATS2 mRNA stability and its expression, subsequently leading to phosphorylation of YAP and its cytoplasmic retention. PMID: 28593479
Dnd1 facilitates apoptosis by increasing the expression of Bim via its competitive combining with miR-221 in Bim-3'UTR. PMID: 28191469
RBM38 and DND1 are repressed in primary acute myeloid leukemia, neutrophil differentiation is dependent on increased expression of both proteins, and they have a role in regulating p21(CIP1) expression during acute promyelocytic leukemia differentiation PMID: 26740055
APOBEC3G inhibits DND1 function to regulate microRNA activity. PMID: 23890083
The increased sensitivity of transformed keratinocytes to miR-21's effects occurs in part through downregulation of the RNA-binding protein DND1 during the transformation process. PMID: 22614019
Results suggest that DND1 may impose another level of translational regulation to modulate expression of critical factors in ES cells. PMID: 21851623
We conclude that germline DND1 mutations are unlikely to contribute significantly to human testicular germ cell tumor susceptibility PMID: 20411342
Cloning of zebrafish dnd1 and identification of human DND1 by database analysis. PMID: 12932328
Unravels a novel role of Dnd1 in protecting certain mRNAs from miRNA-mediated repression. PMID: 18155131
MiR-24 up-regulation reduced the expression of RNA-binding protein dead end 1 (DND1). Knockdown of miR-24 led to enhanced expression of DND1. PMID: 20816961
Observational study of gene-disease association. (HuGE Navigator) PMID: 20411342
The variant, p. Glu86Ala, found in only one case of testiciular germ cell tumor, is within a known functional domain of DND1 and is highly conserved through evolution; mutations in DND1 make, at most, a very small contribution to TGCT susceptibility PMID: 18069663
Observational study of gene-disease association. (HuGE Navigator) PMID: 18069663

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Subcellular Location

Nucleus. Cytoplasm.

Database Links

HGNC: 23799

OMIM: 609385

KEGG: hsa:373863

STRING: 9606.ENSP00000445366

UniGene: Hs.591262

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Protein Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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