DNER Antibody, HRP conjugated

Code CSB-PA818784NB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) DNER Polyclonal antibody
Uniprot No.
Target Names
DNER
Alternative Names
bet antibody; Brain EGF repeat-containing transmembrane protein antibody; Bret antibody; Delta and Notch-like epidermal growth factor-related receptor antibody; Delta notch like EGF repeat containing transmembrane antibody; Delta/notch like EGF repeat containing antibody; Delta/notch-like EGF-related receptor antibody; Dner antibody; DNER_HUMAN antibody; PRO299 antibody; Transmembrane protein Bet antibody; UNQ26 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Peptide sequence from Human Delta and Notch-like epidermal growth factor-related receptor protein (150-168AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis.
Gene References into Functions
  1. quantum dot-based immunofluorescent imaging and quantitative analytical system (QD-IIQAS) is an easy and accurate method for assessing DNER and the DNER expression was an independent prognostic factor in prostate cancer. PMID: 29843212
  2. Collectively, our study identified an unexpected transcriptional repression function of the BET bromodomain and a novel mechanism for TAZ upregulation. PMID: 27717711
  3. our findings show that targeting BET proteins for degradation represents an effective therapeutic strategy for Triple-negative breast cancers (TNBC)treatment PMID: 28209615
  4. is not a Notch ligand PMID: 27622512
  5. we review and discuss the structural biology of BET family BDs and their applications in major diseases. PMID: 27240990
  6. DNER rs1861612 C to T change and variant T genotype may contribute to T2DM in a Chinese Han population PMID: 25300688
  7. These studies implicate DNER as a susceptibility gene for T2DM in American Indians. PMID: 24101674
  8. Our data suggest that clathrin-independent endocytosis is critical for the polarized targeting of somatodendritic proteins(DNER). PMID: 20367751
  9. The inhibition of DNER protein resulted in an increase in adipocyte maturation, partly via a reduction of cell proliferation through elevation of CCAAT-Enhancer-Binding Protein-delta expression. PMID: 20070733
  10. expression in developing and mature central nervous system PMID: 11950833

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Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Tissue Specificity
Expressed in brain, spinal cord and adrenal gland.
Database Links

HGNC: 24456

OMIM: 607299

KEGG: hsa:92737

STRING: 9606.ENSP00000345229

UniGene: Hs.234074

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