DOHH Antibody, HRP conjugated

Code CSB-PA880104LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) DOHH Polyclonal antibody
Uniprot No.
Target Names
DOHH
Alternative Names
Deoxyhypusine dioxygenase antibody; Deoxyhypusine hydroxylase antibody; Deoxyhypusine hydroxylase/monooxygenase antibody; Deoxyhypusine monooxygenase antibody; Dohh antibody; DOHH_HUMAN antibody; hDOHH antibody; HEAT like (PBS lyase) repeat containing 1 antibody; HEAT like PBS lyase repeat containing antibody; HEAT like repeat containing protein 1 antibody; HEAT-like repeat-containing protein 1 antibody; HLRC1 antibody; MGC4293 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Deoxyhypusine hydroxylase protein (79-159AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.
Gene References into Functions
  1. Data describes 3-D structure of hDOHH in two states, hDOHHperoxo (POX) and a complex of the diiron core with glycerol (GLC) providing an explanation for the extreme longevity of POX and illustrate its substrate specificity for deoxyhypusine-eIF-5A. PMID: 25865244
  2. Here, we show that PCBP1 and PCBP2 also deliver iron to deoxyhypusine hydroxylase (DOHH), the dinuclear iron enzyme required for hypusine modification of the translation factor eukaryotic initiation factor 5A. PMID: 24843120
  3. a novel role for miR-331-3p and miR-642-5p in the control of prostate cancer cell growth via the regulation of DOHH expression and eIF5A activity. PMID: 22908221
  4. The structure and function of DOHH are reported. PMID: 16533814
  5. analysis of the deoxyhypusine hydroxylase-eukaryotic translation initiation factor (eIF5A) interaction PMID: 17213197
  6. Resonance Raman experiments show that its blue chromophore arises from a (mu-1,2-peroxo)diiron(III) center that forms in the reaction of the reduced enzyme with O2, so the peroxo form of hDOHH is unusually stable. PMID: 19706422

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Protein Families
Deoxyhypusine hydroxylase family
Database Links

HGNC: 28662

OMIM: 611262

KEGG: hsa:83475

STRING: 9606.ENSP00000250937

UniGene: Hs.515064

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