DOT5 Antibody

Datasheet

Code	CSB-PA328135XA11SVG
Size	US$166
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Image	Western Blot Positive WB detected in: recombinant protein All lanes: DOT5 Antibody at 1:1000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 25 kDa Observed band size: 25 kDa
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Target Background

Product Details

Uniprot No.

P40553

Target Names

DOT5

Alternative Names

Peroxiredoxin DOT5 (Prx) (EC 1.11.1.15) (Disrupter of telomere silencing protein 5) (Nuclear thiol peroxidase) (nTPx) (Thioredoxin peroxidase), DOT5

Species Reactivity

S. cerevisiae

Immunogen

Recombinant S. cerevisiae DOT5 protein (37-118aa)

Immunogen Species

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Affinity-chromatography

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Description

The DOT5 polyclonal antibody is generated through immunization of a rabbit with recombinant S. cerevisiae DOT5 protein (37-118aa). A booster injection is administered to stimulate antibody production. Subsequently, serum containing DOT5 polyclonal antibodies is collected and purified using affinity chromatography. The DOT5 antibody's specificity for S. cerevisiae DOT5 protein has been thoroughly validated through ELISA and WB assays.

S. cerevisiae DOT5 protein functions as a regulator of gene expression in response to osmotic stress, contributing to the yeast cell's ability to adapt and thrive in environments with varying salt concentrations or other osmotically challenging conditions.

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Target Background

Function

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Has a role in telomere silencing, which is the repression of chromatin structure which leads to a stop in the transcription of nearby genes. Also has a role in the regulation of telomere length. Acts as an alkyl-hydroperoxide reductase in the nucleus during post-diauxic growth. Preferentially reduces alkyl-hydroperoxides rather than hydrogen peroxide. Acts as an antioxidant necessary for stationary phase survival.

Gene References into Functions

X-ray analysis of a truncated mutant of yeast nuclear thiol peroxidase, a novel atypical 2-Cys peroxiredoxin PMID: 16511121

Subcellular Location

Nucleus. Chromosome, telomere.

Protein Families

Peroxiredoxin family, BCP/PrxQ subfamily

Database Links

KEGG: sce:YIL010W

STRING: 4932.YIL010W

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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