DPY19L2 Antibody, Biotin conjugated

1. Low PLCZ1 expression is associated with globozoospermia with DPY19L2 deletion. PMID: 29339016
2. provide new evidence, on the one hand, for a severe lack of maturation of the NL, and on the other hand, for dramatic modifications in the location of chromatin-related NL partners in DPY19L2-deleted spermatozoa PMID: 28882431
3. Patients presenting with a monomorphic teratozoospermia such as globozoospermia or macrospermia with more than 85% of the spermatozoa presenting this specific abnormality have been analyzed permitting to identify several key genes for spermatogenesis such as AURKC and DPY19L2. PMID: 27779748
4. Among Tunisian patients with globozoospermia, 8 DPY19L2 haplotypes were found. 61.1% were homozygous for a DPY19L2 deletion. A new splice-site mutation at the junction exon-intron 16 [c.1579_1580+4delAGGTAAinsTCAT] was found in 1 patient. PMID: 26516168
5. The DPY19L2 mutations are the major cause of globozoospermia. PMID: 23512994
6. Analysis of public databases at the DPY19L2 locus paradoxically revealed that, in the general population, duplications were approximately three times as frequent as deletions. PMID: 23555282
7. DPY19L2 is the major gene responsible for globozoospermia and enlarges the spectrum of possible mutations in the gene. PMID: 22653751
8. identification of DPY19L2 deletions and point mutations in European patients shows that globozoospemia caused by a molecular defect of DPY19L2 can be expected in individuals from any ethnic background PMID: 22627659
9. Patients with globozoospermia have a homozygous deletion of DPY19L2. PMID: 21397064
10. The relocation of the gene DPY19L2 within a set of low copy repeats. PMID: 16526957

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HGNC: 19414

OMIM: 613893

KEGG: hsa:283417

STRING: 9606.ENSP00000315988

UniGene: Hs.533644