DUS2 Antibody

Datasheet

Code	CSB-PA062483
Size	US$297
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Image	Western blot analysis of extracts from RAW264.7 cells, using DUS2L antibody. Immunohistochemistry analysis of paraffin-embedded human skeletal muscle using DUS2L antibody.
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) DUS2 Polyclonal antibody

Uniprot No.

Q9NX74

Target Names

DUS2

Alternative Names

DUS2 antibody; DUS2LtRNA-dihydrouridine(20) synthase [NAD(P)+]-like antibody; EC 1.3.1.91 antibody; Dihydrouridine synthase 2 antibody; Up-regulated in lung cancer protein 8 antibody; URLC8 antibody; tRNA-dihydrouridine synthase 2-like antibody; hDUS2 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthesized peptide derived from C-terminal of Human DUS2L.

Immunogen Species

Homo sapiens (Human)

Clonality

Polyclonal

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Tested Applications

ELISA,WB,IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:3000
IHC	1:50-1:100

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Dihydrouridine synthase. Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR.

Gene References into Functions

Here, the X-ray crystal structure of a construct of hDus2 encompassing the catalytic and tRNA-recognition domains (residues 1-340) determined at 1.9 A resolution is presented. PMID: 26143927
This is the first reported case of a tRNA-modifying enzyme (dihydrouridine synthase 2) carrying a dsRNA binding domain used to bind tRNAs. PMID: 26429968
crystals belonged to space group P2(1) and contained a single molecule of HsDus2L in the asymmetric unit PMID: 22442237
hDUS2 interacts with protein kinase PKR through its dsRNA binding/dimerization domain and inhibits its kinase activity. PMID: 18096616

Subcellular Location

Cytoplasm. Endoplasmic reticulum. Note=Mainly at the endoplasmic reticulum.

Protein Families

Dus family, Dus2 subfamily

Tissue Specificity

Weak expression in heart, placenta and skeletal muscle. Up-regulated in most lung cancer cells (at protein level).

Database Links

HGNC: 26014

OMIM: 609707

KEGG: hsa:54920

STRING: 9606.ENSP00000351769

UniGene: Hs.534460

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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