DUS2 Antibody

Code CSB-PA030155
Size US$100
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Product Details

Uniprot No.
Target Names
DUS2
Alternative Names
DUS2 antibody; DUS2LtRNA-dihydrouridine(20) synthase [NAD(P)+]-like antibody; EC 1.3.1.91 antibody; Dihydrouridine synthase 2 antibody; Up-regulated in lung cancer protein 8 antibody; URLC8 antibody; tRNA-dihydrouridine synthase 2-like antibody; hDUS2 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthesized peptide derived from the C-terminal region of Human DUS2L.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IHC, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:20000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Dihydrouridine synthase. Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR.
Gene References into Functions
  1. Here, the X-ray crystal structure of a construct of hDus2 encompassing the catalytic and tRNA-recognition domains (residues 1-340) determined at 1.9 A resolution is presented. PMID: 26143927
  2. This is the first reported case of a tRNA-modifying enzyme (dihydrouridine synthase 2) carrying a dsRNA binding domain used to bind tRNAs. PMID: 26429968
  3. crystals belonged to space group P2(1) and contained a single molecule of HsDus2L in the asymmetric unit PMID: 22442237
  4. hDUS2 interacts with protein kinase PKR through its dsRNA binding/dimerization domain and inhibits its kinase activity. PMID: 18096616
Subcellular Location
Cytoplasm. Endoplasmic reticulum. Note=Mainly at the endoplasmic reticulum.
Protein Families
Dus family, Dus2 subfamily
Tissue Specificity
Weak expression in heart, placenta and skeletal muscle. Up-regulated in most lung cancer cells (at protein level).
Database Links

HGNC: 26014

OMIM: 609707

KEGG: hsa:54920

STRING: 9606.ENSP00000351769

UniGene: Hs.534460

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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