DUSP10 Antibody

Code CSB-PA006797
Size US$100
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  • Western Blot analysis of 3T3 cells using DUSP10 Polyclonal Antibody
  • Immunohistochemical analysis of paraffin-embedded human meningioma. DUSP10 Antibody was diluted at 1:200.
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Product Details

Uniprot No.
Target Names
Alternative Names
Dual specificity phosphatase 10 antibody; Dual specificity phosphatase MKP 5 antibody; Dual specificity phosphatase MKP5 antibody; Dual specificity protein phosphatase 10 antibody; DUS10_HUMAN antibody; DUSP 10 antibody; DUSP10 antibody; DUSP10 protein antibody; MAP kinase phosphatase 5 antibody; Mitogen activated protein kinase phosphatase 5 antibody; Mitogen-activated protein kinase phosphatase 5 antibody; MKP 5 antibody; MKP-5 antibody; MKP5 antibody; Serine/threonine specific protein phosphatase antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from the C-terminal region of Human MKP-5.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IHC, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:25-1:200
ELISA 1:40000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38.
Gene References into Functions
  1. Our findings uncover novel associations of progressive supranuclear palsy with SLCO1A2 (rs11568563) and DUSP10 (rs6687758) variants PMID: 29986742
  2. High DUSP10 expression is associated with Metastasis of Hepatocellular Carcinoma. PMID: 28674078
  3. Increased Dusp10 expression is associated with better survival rate in colorectal cancer patients. PMID: 25772234
  4. In females, three SNPs were associated with decreased colorectal cancer risk: rs11118838, rs12724393, and rs908858. However, in males, only one SNP, rs908858, was associated with decreased colorectal cancer risk. PMID: 25973098
  5. Data suggest that vitamin D receptor target genes (DUSP10; THBD, thrombomodulin; NRIP1, nuclear receptor interacting protein 1; TRAK1, trafficking protein kinesin binding 1) can be used as markers for individual's response to vitamin D3 supplements. PMID: 24975273
  6. Certain mutations in DUSP10 correlate with the incidence of colorectal cancer(CRC). Thus, the function of the DUSP10 gene product may contribute toward CRC in the Han Chinese population. PMID: 23872954
  7. Single nucleotide polymorphism in DUSP10 gene is associated with celiac disease. PMID: 23936387
  8. Depletion of miR-181 family members by miRNA inhibitors enhanced the expression of MKP-5 and suppressed the phosphorylation of p38 MAPK after exposure to PAHs, which promotes cancer cell migration. PMID: 23993976
  9. Data indicate that the activities of phosphoprotein phosphatases MKP5 and MKP7 were determined in the system. PMID: 23233447
  10. MKP-5 interacts with ERK, retains it in the cytoplasm, suppresses its activation and downregulates ERK-dependent transcription. PMID: 22711061
  11. A distinct interaction mode revealed by the crystal structure of the kinase p38alpha with the MAPK binding domain of the phosphatase MKP5. PMID: 22375048
  12. DUSPs 10 and 16 are positive regulators of activation, apparently acting by modulating cross-talk between the p38 and ERK pathways. PMID: 22245064
  13. a function for ASC that is distinct from the inflammasome in modulating MAPK activity and chemokine expression and further identify DUSP10 as a novel ASC target. PMID: 21487011
  14. Structural information provides an explanation of constitutive activity of MKP5 as well as the structural insight into substrate-induced activation occurred in other MKPs. PMID: 16806267
  15. Mitogen-activated protein kinase phosphatase-5 (MKP5) mediates anti-inflammatory activities of phytochemicals curcumin, resveratrol and [6]-gingerol. PMID: 17151092
  16. Catalytic domain of MKP5 is in an active conformation, and two loops in the active site have backbone shifts of up to 5 A. PMID: 17400920
  17. The transcription factor ATF2, which is phosphorylated and activated by JNK, is a critical mediator for inducible expression of DUSP1 and DUSP10 in this signaling pathway. PMID: 17681939
  18. p38 MAP kinase down-regulates extracellular signal-regulated kinase via activation of MKP-3 in human monocytes exposed to asbestos to enhance TNF-alpha gene expression. PMID: 18314537

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Subcellular Location
Cytoplasm. Nucleus.
Protein Families
Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily
Tissue Specificity
Expressed in keratinocytes (at protein level). Detected in brain.
Database Links

HGNC: 3065

OMIM: 608867

KEGG: hsa:11221

STRING: 9606.ENSP00000355866

UniGene: Hs.497822

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