DYNC1LI1 Antibody, Biotin conjugated

Code CSB-PA897312LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) DYNC1LI1 Polyclonal antibody
Uniprot No.
Target Names
DYNC1LI1
Alternative Names
Cytoplasmic dynein 1 light intermediate chain 1 antibody; cytosolic antibody; DC1L1_HUMAN antibody; DLC-A antibody; DNCLI1 antibody; dync1li1 antibody; Dynein cytoplasmic 1 light intermediate chain 1 antibody; Dynein cytoplasmic light intermediate polypeptide 1 antibody; Dynein light chain A antibody; Dynein light intermediate chain 1 antibody; Dynein light intermediate chain 1 cytosolic antibody; FLJ10219 antibody; LIC1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Cytoplasmic dynein 1 light intermediate chain 1 protein (167-233AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores.
Gene References into Functions
  1. conserved mechanism of effector interaction with dynein-dynactin necessary for processive motility PMID: 29515126
  2. the DYNC1I1 deficiency, a neuron-specific dynein intermediate chain, causes neuronal atrophy in primary hippocampal neurons. PMID: 27510948
  3. This work reveals the structural details of Hook3's interaction with dynein and offers insight into how cargo adaptors form processive dynein-dynactin motor complexes. PMID: 27482052
  4. although dynein lacking light intermediate chains (LICs) drives microtubule gliding at normal rates, the LICs are required for the formation and maintenance of a bipolar spindle. PMID: 25422374
  5. using a variety of complementary approaches, our results indicate a novel specific role for the LICs in dynein recruitment to components of the late endocytic pathway. PMID: 21169557
  6. Rab11a, FIP3 and DLIC-1 form a ternary complex and DLIC-1 colocalises with endogenous FIP3 and Rab11a in A431 cells. PMID: 20026645
  7. Dynein light intermediate chain 1 is required for progress through the spindle assembly checkpoint PMID: 19229290

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Subcellular Location
Cytoplasm. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole.
Protein Families
Dynein light intermediate chain family
Database Links

HGNC: 18745

OMIM: 615890

KEGG: hsa:51143

STRING: 9606.ENSP00000273130

UniGene: Hs.529495

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