DYNC1LI1 Antibody

Datasheet

Code	CSB-PA897312LA01HU
Size	US$166
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Image	IHC image of CSB-PA897312LA01HU diluted at 1:200 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) DYNC1LI1 Polyclonal antibody

Uniprot No.

Q9Y6G9

Target Names

DYNC1LI1

Alternative Names

Cytoplasmic dynein 1 light intermediate chain 1 antibody; cytosolic antibody; DC1L1_HUMAN antibody; DLC-A antibody; DNCLI1 antibody; dync1li1 antibody; Dynein cytoplasmic 1 light intermediate chain 1 antibody; Dynein cytoplasmic light intermediate polypeptide 1 antibody; Dynein light chain A antibody; Dynein light intermediate chain 1 antibody; Dynein light intermediate chain 1 cytosolic antibody; FLJ10219 antibody; LIC1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Cytoplasmic dynein 1 light intermediate chain 1 protein (167-233AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The DYNC1LI1 Antibody (Product code: CSB-PA897312LA01HU) is Non-conjugated. For DYNC1LI1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA897312LB01HU	DYNC1LI1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA897312LC01HU	DYNC1LI1 Antibody, FITC conjugated
Biotin	CSB-PA897312LD01HU	DYNC1LI1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:200-1:500

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores.

Gene References into Functions

conserved mechanism of effector interaction with dynein-dynactin necessary for processive motility PMID: 29515126
the DYNC1I1 deficiency, a neuron-specific dynein intermediate chain, causes neuronal atrophy in primary hippocampal neurons. PMID: 27510948
This work reveals the structural details of Hook3's interaction with dynein and offers insight into how cargo adaptors form processive dynein-dynactin motor complexes. PMID: 27482052
although dynein lacking light intermediate chains (LICs) drives microtubule gliding at normal rates, the LICs are required for the formation and maintenance of a bipolar spindle. PMID: 25422374
using a variety of complementary approaches, our results indicate a novel specific role for the LICs in dynein recruitment to components of the late endocytic pathway. PMID: 21169557
Rab11a, FIP3 and DLIC-1 form a ternary complex and DLIC-1 colocalises with endogenous FIP3 and Rab11a in A431 cells. PMID: 20026645
Dynein light intermediate chain 1 is required for progress through the spindle assembly checkpoint PMID: 19229290

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Subcellular Location

Cytoplasm. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole.

Protein Families

Dynein light intermediate chain family

Database Links

HGNC: 18745

OMIM: 615890

KEGG: hsa:51143

STRING: 9606.ENSP00000273130

UniGene: Hs.529495

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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