DYNC1LI2 Antibody

Datasheet

Code	CSB-PA007296GA01HU
Size	$600
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Product Details
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Target Background

Product Details

Uniprot No.

O43237

Target Names

DYNC1LI2

Alternative Names

Cytoplasmic dynein 1 light intermediate chain 2 antibody; cytosolic antibody; DC1L2_HUMAN antibody; DNCLI2 antibody; Dync1li2 antibody; Dynein cytoplasmic 1 light intermediate chain 2 antibody; Dynein light intermediate chain 2 antibody; dynein light intermediate chain 2 cytosolic antibody; dynein; cytoplasmic; light intermediate polypeptide 2 antibody; LIC-2 antibody; LIC2 antibody; LIC53/55 antibody; OTTHUMP00000174820 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human DYNC1LI2

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.

Gene References into Functions

Cortically localized dynein, essential for maintaining correct spindle orientation, consists majorly of LIC2-dynein, which interacts with cortical 14-3-3 epsilon- zeta and Par3, conserved proteins required for orienting the spindle. PMID: 28003657
This study uncovers a novel functional hierarchy during mitotic checkpoint inactivation between the closely related but homologous LIC subunits of cytoplasmic dynein. PMID: 27441562
although dynein lacking light intermediate chains (LICs) drives microtubule gliding at normal rates, the LICs are required for the formation and maintenance of a bipolar spindle. PMID: 25422374
using a variety of complementary approaches, our results indicate a novel specific role for the LICs in dynein recruitment to components of the late endocytic pathway. PMID: 21169557
FIP3 was identified as the first membrane-associated interacting-partner for DLIC-2. PMID: 20214888

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Subcellular Location

Cytoplasm, cytoskeleton.

Protein Families

Dynein light intermediate chain family

Database Links

HGNC: 2966

OMIM: 611406

KEGG: hsa:1783

STRING: 9606.ENSP00000258198

UniGene: Hs.369068

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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