DYNC2LI1 Antibody

Code CSB-PA844722ESR1HU
Size US$166
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Image
  • Western blot
    All lanes: DYNC2LI1 antibody at 1.17µg/ml
    Lane 1: 293T whole cell lysate
    Lane 2: A549 whole cell lysate
    Lane 3: Mouse gonadal tissue
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 40, 38, 23, 16 kDa
    Observed band size: 40 kDa

  • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA844722ESR1HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human glioma using CSB-PA844722ESR1HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) DYNC2LI1 Polyclonal antibody
Uniprot No.
Target Names
DYNC2LI1
Alternative Names
CGI-60 antibody; Cytoplasmic dynein 2 light intermediate chain 1 antibody; D2LIC antibody; DC2L1_HUMAN antibody; DYNC2LI1 antibody; Dynein 2 light intermediate chain antibody; Dynein, cytoplasmic 2, light intermediate chain 1 antibody; LIC3 antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human Cytoplasmic dynein 2 light intermediate chain 1 protein (1-352AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system, facilitating the assembly of these organelles. Involved in the regulation of ciliary length.
Gene References into Functions
  1. depletion of DYNC2LI1 induced altered cilia morphology with broadened ciliary tips and accumulation of intraflagellar transport complexes (IFT-B) complex proteins in accordance with retrograde IFT defects. PMID: 26130459
  2. DYNC2LI1 is essential for dynein-2 complex stability and that mutations in DYNC2LI1 result in variable length, including hyperelongated, cilia, Hedgehog pathway impairment and ciliary IFT accumulations, causing short rib polydactyly syndrome. PMID: 26077881
Involvement in disease
Short-rib thoracic dysplasia 15 with polydactyly (SRTD15)
Subcellular Location
Golgi apparatus. Cytoplasm. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Protein Families
Dynein light intermediate chain family
Tissue Specificity
Expressed in bone, brain, kidney, and cartilage. Lower expression in heart, liver, lung, placenta and thymus.
Database Links

HGNC: 24595

OMIM: 617083

KEGG: hsa:51626

STRING: 9606.ENSP00000260605

UniGene: Hs.371597

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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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