DNAAF4 Antibody

1. that endogenous DYX1C1 localizes to the base of the cilium, whereas DCDC2 localizes along the entire axoneme of the cilium PMID: 27451412
2. promoter SNP rs12899331 of DYX1C1 may contribute towards the manifestation of DD. This study supports the association of DYX1C1 with DD in an Indian population PMID: 24362368
3. results demonstrate that DYX1C1 can modulate the expression of genes involved in cell migration and nervous system development and associates with a number of cytoskeletal proteins. PMID: 23036959
4. DYX1C1 is required for axonemal dynein assembly and ciliary motility. PMID: 23872636
5. The results of this study do not provide evidence for association between the putatively functional single nucleotide polymorphisms -3G/A and 1249G/T in DYX1C1 and reading disabilities. PMID: 23341075
6. Gene-by-environment effects were found between some specified environmental moderators (i.e. maternal smoke during pregnancy, birth weight and socio-economic status) and the DYX1C1-1259C/G marker PMID: 23176554
7. results suggested that the 931C > T variant in KIAA0319, but not the -3G > A in DYX1C1, was significantly associated with the risk of dyslexia PMID: 23065966
8. DYX1C1 influences reading development in the general Chinese population and supports a universal effect of this gene. PMID: 23028439
9. The results of this study found that DYX1C1 gene contained polymorphisms that were significantly associated with white matter volume in the left temporo-parietal region and that white matter volume influenced reading ability. PMID: 22683091
10. Mutations in cilia co-expressed DCDC2, DYX1C1 and KIAA0319 genes are associated with a cognitive neurological disorder, dyslexia. PMID: 22558177
11. the expression of DYX1C1 in breast cancer is associated with several clinicopathological parameters and that loss of DYX1C1 correlates with a more aggressive disease, in turn indicating that DYX1C1 is a potential prognostic biomarker in breast cancer. PMID: 22375924
12. A single nucleotide polymorphism previously shown to be associated with dyslexia and located in the cis-regulatory region of DYX1C1 may alter the epigenetic and endocrine regulation of this gene. PMID: 22383464
13. findings suggest that DYX1C1 is associated with dyslexia in people of Chinese ethnicity. PMID: 21599957
14. No statistically significant associations were found between DCDC2 or DYX1C1 and language phenotypes. Both DCDC2 and DYX1C1 DD susceptibility genes appear to have a pleiotropic role on mathematics but not language phenotypes. PMID: 21046216
15. At this point, there is no statistical evidence of association between the allelic variation in the three candidate genes and DD in our sample. PMID: 21203818
16. Association signals were detected for several single nucleotide polymorphisms within DYX1C1 with both the reading and spelling tests PMID: 20846247
17. Results suggest that DYX1C1 influences reading and spelling ability with additional effects on short-term information storage or rehearsal. Missense mutation rs17819126 is a potential functional basis for the association of DYX1C1 with dyslexia. PMID: 19901951
18. Functional characterization of the homologous rat protein. PMID: 16989952
19. DYX1C1 should be regarded as a candidate gene for developmental dyslexia and localizes to a fraction of cortical neurons and white matter glial cells PMID: 12954984
20. Findings provide support for EKN1 as a risk locus for dyslexia and as contributing to reading component processes and reading-related abilities. PMID: 15249932
21. Thus it seems unlikely that DYX1C1 gene would be involved in the genetic etiology of autism in Finnish patients. PMID: 15470369
22. DYX1C1 is unlikely to be a susceptibility gene for developmental dyslexia PMID: 15477871
23. Single nucleotide polymorphisms of DYX1C1 are not associated with dyslexia susceptibility in a large sample of sibling pairs. PMID: 15520411
24. disequilibrium with DYX1C1 is more saliently explained in Italian dyslexics by short-term memory PMID: 17309662
25. The observation of weak evidence for transmission disequilibrium for one of the two studied polymorphisms in DYX1C1 suggests involvement of this gene in dyslexia. PMID: 17450541
26. TFII-I, PARP1, and SFPQ proteins, each previously implicated in gene regulation, form a complex controlling transcription of DYX1C1. Allelic differences in the promoter or 5'UTR of DYX1C1 may affect factor binding and thus regulation of the gene. PMID: 18445785
27. Alternatively spliced transcript variants of the DYX1C1 gene may be used as cancer biomarkers to detect colorectal cancer. PMID: 18618141
28. The contribution of DYX1C1 to dyslexia in a sample of 366 trios of German descent, was investigated. PMID: 19240663
29. The DYX1C1 is a novel Hsp70 and Hsp90-interacting co-chaperone protein and its expression is associated with malignancy. PMID: 19277710
30. DYX1C1 interacts with both ERs in the presence of 17beta-estradiol in neurons. PMID: 19423554

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HGNC: 21493

OMIM: 127700

KEGG: hsa:161582

STRING: 9606.ENSP00000323275

UniGene: Hs.126403