E6 Antibody

Code CSB-PA334186LA01HNY
Size US$166
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Product Details

Full Product Name
Rabbit anti-Human papillomavirus type 52 E6 Polyclonal antibody
Uniprot No.
Target Names
E6
Alternative Names
E6 antibody; Protein E6 antibody
Raised in
Rabbit
Species Reactivity
Human papillomavirus type 52
Immunogen
Recombinant Human papillomavirus type 52 Protein E6 protein (1-148AA)
Immunogen Species
Human papillomavirus type 52
Conjugate
Non-conjugated

The E6 Antibody (Product code: CSB-PA334186LA01HNY) is Non-conjugated. For E6 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA334186LB01HNY E6 Antibody, HRP conjugated ELISA
FITC CSB-PA334186LC01HNY E6 Antibody, FITC conjugated
Biotin CSB-PA334186LD01HNY E6 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Plays a major role in the induction and maintenance of cellular transformation. Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins. E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation. In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development. The complex E6/E6AP targets several other substrates to degradation via the proteasome including host DLG1 or NFX1, a repressor of human telomerase reverse transcriptase (hTERT). The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization. Other cellular targets including BAK1, Fas-associated death domain-containing protein (FADD) and procaspase 8, are degraded by E6/E6AP causing inhibition of apoptosis. E6 also inhibits immune response by interacting with host IRF3 and TYK2. These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway.
Subcellular Location
Host cytoplasm. Host nucleus.
Protein Families
Papillomaviridae E6 protein family
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