EDC3 Antibody

Datasheet

Code	CSB-PA007393GA01HU
Size	$600
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q96F86

Target Names

EDC3

Alternative Names

EDC 3 antibody; edc3 antibody; EDC3_HUMAN antibody; enhancer of mRNA decapping 3 homolog (S. cerevisiae) antibody; Enhancer of mRNA decapping 3 homolog antibody; Enhancer of mRNA decapping 3; S. cerevisiae; homolog of antibody; Enhancer of mRNA decapping protein 3 antibody; Enhancer of mRNA-decapping protein 3 antibody; FLJ21128 antibody; FLJ31777 antibody; hYjeF_N2 antibody; hYjeF_N2-15q23 antibody; LSM 16 antibody; LSM16 antibody; LSM16 homolog (EDC3 S. cerevisiae) antibody; LSM16 homolog (EDC3; S. cerevisiae) antibody; LSM16 homolog antibody; YJDC antibody; YjeF domain containing antibody; YjeF domain containing protein 1 antibody; YjeF domain containing protein antibody; YjeF domain-containing protein 1 antibody; YjeF N-terminal domain-containing protein 2 antibody; YjeF_N2 antibody; YJEFN2 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human EDC3

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB,IHC

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping. May play a role in spermiogenesis and oogenesis.

Gene References into Functions

In vitro decapping assays showed that altered EDC3 is unable to enhance DCP2 decapping at low concentrations and even inhibits DCP2 decapping at high concentration. PMID: 25701870
The modular architecture enables EDC3 to interact with multiple components of the decapping machinery, including DCP1, DCP2, and Me31B. PMID: 17923697
The dimerization interface of Edc3 is highly conserved in eukaryotes despite the overall low sequence homology across species; structure-based site-directed mutagenesis revealed dimerization is required for efficient RNA binding, P-body formation PMID: 18678652
Structural basis for the mutually exclusive anchoring of P body components EDC3 and Tral to the DEAD box protein DDX6/Me31B. PMID: 19285948

Involvement in disease

Mental retardation, autosomal recessive 50 (MRT50)

Subcellular Location

Cytoplasm, P-body. Note=Processing bodies (PB).

Protein Families

EDC3 family

Tissue Specificity

Expressed in theca and granulosa cells in ovary, and in spermatids of the meiotic division part II and apical membrane of Sertoli cells in testis (at protein level). Also expressed in brain and mammary gland.

Database Links

HGNC: 26114

OMIM: 609842

KEGG: hsa:80153

STRING: 9606.ENSP00000320503

UniGene: Hs.682454

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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