EEF1D Antibody

Code CSB-PA007431GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
EEF1D
Alternative Names
Antigen NY CO 4 antibody; Antigen NY-CO-4 antibody; EEF 1D antibody; EEF1D antibody; EF 1 delta antibody; EF 1D antibody; EF-1-delta antibody; EF1D antibody; EF1D_HUMAN antibody; Elongation factor 1 delta antibody; Elongation factor 1-delta antibody; eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) antibody; Eukaryotic translation elongation factor 1 delta antibody; FP1047 antibody; Guanine nucleotide exchange protein antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human EEF1D
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs to the ribosome.; Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE).
Gene References into Functions
  1. eukaryotic translation elongation factor 1delta knockdown in oral squamous cell carcinoma reduced cell proliferation and induced EMT (epithelial-mesenchymal transition) phenotypes PMID: 26823560
  2. Taken together, our data suggest EFF1D functions as a novel negative regulator of SIAH-1 PMID: 21633900
  3. overexpression is positively correlated with malignant transformation of 16HBE cells induced by CdC12, but is not correlated with DNA mutations PMID: 20514991
  4. These results further confirm that overexpression of TEF-1 delta is oncogenic and the antisense TEF-1 delta mRNA expression reverses its oncogenic potential. PMID: 12210501
  5. Interaction between HrHRF and EF-1delta taken with some of the recently published information concerning the TCTP (HrHRF) mentioned above suggest a possible intracellular role for TCTP/HrHRF. PMID: 15062873
  6. Increased EF-1 delta mRNA expression is associated with lymph node metastases and advanced disease stages in esophageal carcinoma PMID: 15199388
  7. Gain of 8q-mapped EF-1 delta is associated with adverse outcome in Medulloblastoma. PMID: 16968546
  8. Repression of deltaEF1 plays a key role in mediating BMP-6-induced transcriptional activation of E-cadherin in breast cancer cells. PMID: 17997862

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Subcellular Location
[Isoform 2]: Nucleus.
Protein Families
EF-1-beta/EF-1-delta family
Tissue Specificity
Isoform 2 is specifically expressed in brain, cerebellum and testis.
Database Links

HGNC: 3211

OMIM: 130592

KEGG: hsa:1936

STRING: 9606.ENSP00000391944

UniGene: Hs.333388

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