EEF1E1 Antibody

Datasheet

Code	CSB-PA007432LA01HU
Size	US$166
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Image	Western blot All lanes: EEF1E1 antibody at 2µg/ml + HepG2 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 20, 16 kDa Observed band size: 20 kDa Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA007432LA01HU at dilution of 1:100 Immunofluorescent analysis of Hela cells using CSB-PA007432LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) EEF1E1 Polyclonal antibody

Uniprot No.

O43324

Target Names

EEF1E1

Alternative Names

AIMP 3 antibody; AIMP3 antibody; Aminoacyl tRNA synthetase complex interacting multifunctional protein 3 antibody; Aminoacyl tRNA synthetase complex-interacting multifunctional protein 3 antibody; ARS interacting multifunctional protein 3 antibody; EEF1E1 antibody; Elongation factor p18 antibody; Eukaryotic translation elongation factor 1 epsilon 1 antibody; Eukaryotic translation elongation factor 1 epsilon-1 antibody; Homolog of rat elongation factor p18 antibody; MCA3_HUMAN antibody; Multisynthase complex auxiliary component p18 antibody; Multisynthetase complex auxiliary component p18 antibody; p18 antibody; p18 component of aminoacyl tRNA synthetase complex antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Eukaryotic translation elongation factor 1 epsilon-1 protein (2-174AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The EEF1E1 Antibody (Product code: CSB-PA007432LA01HU) is Non-conjugated. For EEF1E1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA007432LB01HU	EEF1E1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA007432LC01HU	EEF1E1 Antibody, FITC conjugated
Biotin	CSB-PA007432LD01HU	EEF1E1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Positive modulator of ATM response to DNA damage.

Gene References into Functions

LmnA binds AIMP3 via its extreme C-terminus. Together these findings provide a structural insight for understanding the interaction between AIMP3 and LmnA in AIMP3 degradation. PMID: 28797100
AIMP3 was shown to be involved in the cellular aging of human mesenchymal stem cells. PMID: 25465621
Identification of EEf1E1 and OBFC2B as novel BRCA1-partner genes in the DNA double-strand break repair pathway. PMID: 24104880
AIMP3 stabilizes and protects methionyl-tRNA synthetase and eIF2gamma through the binding interactions. PMID: 23306449
AIMP3 is a critical mediator of Met-tRNA(i)(Met) transfer from methionyl-tRNA synthetase to eIF2 complex for the accurate and efficient translation initiation PMID: 22867704
Data show that aminoacyl-tRNA synthetase-interacting multifunctional protein-3 (AIMP3)/p18 is released from aminoacyl-tRNA synthetase-interacting multifunctional protein-3 (AIMP3) by UV irradiation-induced stress. PMID: 22106287
Decreased expression of AIMP3 in gastric and colorectal cancer tissues suggests that down-regulation of this protein may be related to inactivation of the tumor suppressor functions of AIMP proteins and might play a role in the development of GC and CRC. PMID: 21789020
p18 is a haploinsufficient tumor suppressor and a key factor for ATM/ATR-mediated p53 activation. PMID: 15680327
analysis of the three-dimensional structure and residues of the novel tumor suppressor AIMP3/p18 required for the interaction with PMID: 18343821
No EEF1E1 mutations were detected in human cancer specimens. PMID: 19024604

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Subcellular Location

Cytoplasm. Cytoplasm, cytosol. Nucleus. Note=Cytoplasmic under growth arrest conditions. Translocated into the nucleus when growth resumes (S phase) and following DNA damage.

Tissue Specificity

Down-regulated in various cancer tissues.

Database Links

HGNC: 3212

OMIM: 609206

KEGG: hsa:9521

STRING: 9606.ENSP00000369038

UniGene: Hs.602353

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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