EIF4A3 Antibody

1. FAL1 may work as a ceRNA to modulate AKT1 expression via competitively binding to miR-637 in HSCR. PMID: 30062828
2. we firstly report that the lncRNA H19 recruits eIF4A3 and promotes the colorectal cancer cell proliferation PMID: 26989025
3. High EIF4A expression is associated with malignant peripheral nerve sheath tumors and vestibular schwannomas. PMID: 26951381
4. MYC, DUX4, and EIF4A3 might contribute to facioscapulohumeral dystrophy pathophysiology PMID: 28273136
5. Host eIF4AIII RNA helicase is required for efficient human cytomegalovirus replication. PMID: 26773380
6. EIF4A3 is a gene involved in RNA metabolism, plays a role in mandible, laryngeal, and limb morphogenesis. Richieri-Costa-Pereira syndrome is caused by mutations in EIF4A3. PMID: 24360810
7. The binding mode of CWC22 to eIF4AIII reveals a facet of how MIF4G domains use their versatile structural frameworks to activate or inhibit DEAD-box proteins. PMID: 24218557
8. CWC22 escorts the helicase eIF4AIII to spliceosomes and promotes exon junction complex assembly PMID: 22961380
9. demonstrate direct physical interactions between yeast Sgd1p and Fal1p, and between their human orthologs (NOM1 and eIF4AIII) in vitro and in vivo, identifying human NOM1 as a missing eIF4G-like interacting partner of eIF4AIII PMID: 21576267
10. identification of eIF4AIII and Barentsz as components of a conserved protein complex that is essential for mRNA localization in flies and nonsense-mediated mRNA decay in mammals PMID: 14973490
11. eIF4AIII represents a new functional class of DExH/D box proteins that act as RNA clamps or 'place holders' for the sequence-independent attachment of additional factors to RNAs. PMID: 15034551
12. detection of autoantibodies to DDX48 may have clinical utility for the improved diagnosis of pancreatic cancer PMID: 15796914
13. The stable association of multiprotein exon junction complex core with RNA is maintained by inhibition of eIF4AIII ATPase activity by MAGOH-Y14. PMID: 16170325
14. crystal structure of a tetrameric exon junction core complex containing the DEAD-box adenosine triphosphatase eukaryotic initiation factor 4AIII bound to an ATP analog, MAGOH, Y14, a fragment of MLN51, and a polyuracil mRNA mimic PMID: 16931718
15. Although it is dispensable for pre-mRNA splicing in vitro, eIF4A3 is required for splicing-dependent loading of the Y14-Magoh core heterodimer onto mRNA. PMID: 17606899
16. Data show that eIF4AIII, a core exon junction complex (EJC) component loaded onto mRNAs by pre-mRNA splicing, is associated with neuronal mRNA granules and dendritic mRNAs. PMID: 17632064
17. The nonsense-mediated-decay mRNA surveillance pathway downregulates aberrant E-cadherin transcripts in gastric cancer cells and in CDH1 mutation carriers. PMID: 18427545
18. NMP 265, a common part of the nuclear matrix, is located in the nucleus via an N-terminal amino acid sequence. PMID: 10623621

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HGNC: 18683

OMIM: 268305

KEGG: hsa:9775

STRING: 9606.ENSP00000269349

UniGene: Hs.389649