EIF4ENIF1 Antibody

1. we demonstrate that joint deletion of two short conserved motifs that bind UNR and DDX6 relieves repression of 4E-T-bound mRNA, in part reliant on the 4E-T-DDX6-CNOT1 axis. PMID: 27342281
2. our data support a model where 4E-T promotes mRNA turnover by physically linking the 3'-terminal mRNA decay machinery to the 5' cap PMID: 26027925
3. neural precursors are transcriptionally primed to generate neurons, but an eIF4E/4E-T complex sequesters and represses translation of proneurogenic proteins to determine appropriate neurogenesis. PMID: 25456498
4. that while both eIF4E1 and eIF4E2 bind 4E-T via the canonical YX 4Lvarphi sequence, nearby downstream sequences also influence eIF4E:4E-T interactions PMID: 23991149
5. This work has demonstrated the conserved yet unpredicted and surprising translational control of bound mRNAs by 4E-T, which does not involve eIF4E, nor P-body components. PMID: 24335285
6. Data demonstrate that EIF4ENIF1 is associated with dominantly inherited primary ovarian insufficiency. PMID: 23902945
7. The c-Jun N-terminal kinase (JNK) is targeted to processing bodies in response to oxidative stress and promotes the phosphorylation of 4E-T. PMID: 22966201
8. human P bodies contain the cap-binding protein eIF4E and the related factor eIF4E-transporter (eIF4E-T), suggesting novel roles for these proteins in targeting mRNAs for 5' --> 3' degradation PMID: 15840819
9. A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay is described. PMID: 16157702
10. Overexpression of eIF4E-T triggers the movement of eIF4E into the processing bodies. PMID: 18343217
11. Hsp90 probably contributes to the correct localization of eIF4E and 4E-T to stress granules and also to the interaction between eIF4E and eIF4G, both of which may be needed for eIF4E to acquire the physiological functionality PMID: 19850929

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HGNC: 16687

OMIM: 607445

KEGG: hsa:56478

STRING: 9606.ENSP00000328103

UniGene: Hs.517559