ELL2 Antibody

1. Study in CD138+ plasma cells from 1630 multiple myeloma (MM) patients show that the MM risk allele at 5q15 lowers ELL2 expression in these cells, but not in peripheral blood or other tissues. PMID: 29695719
2. Study reports the 2.0-A resolution crystal structure of the human ELL2 C-terminal domain bound to its 50-residue binding site on AFF4, the ELLBow. The ELLBow consists of an N-terminal helix followed by an extended hairpin and occupies most of the concave surface of ELL2. This surface is important for the ability of ELL2 to promote HIV-1 Tat-mediated proviral transcription. PMID: 28134250
3. Knockdown of RNA polymerase II elongation factor ELL2 (ELL2) sensitized prostate cancer cells to DNA damage and overexpression of ELL2 protected prostate cancer cells from DNA damage. PMID: 29179998
4. expression is consistent with inherited genetic variation contributing to arrest of plasma cell development, facilitating multiple myeloma clonal expansion. PMID: 28903037
5. Results provide the first evidence that ELL2 is a direct target of miR-299 and increased ELL2 expression and down-regulation of miR-299 are associated with GBM progression and poor prognosis in patients. PMID: 28531325
6. Selective expression of the transcription elongation factor ELL3 in B cells prior to ELL2 drives proliferation and survival PMID: 28858629
7. These results suggest that ELL2 and its pathway genes likely play an important role in the development and progression of prostate cancer. PMID: 28870994
8. multiple myeloma risk allele harbours a Thr298Ala missense variant in an ELL2 domain required for transcription elongation PMID: 26007630
9. Tax transactivates the ELL2 promoter in HTLV-1-infected T-cells. PMID: 25058508
10. Loss of ELL2 in B cells results in decreased Igh secretory mRNA and decreased expression of Ig light chain plus genes involved in the unfolded protein response like XBP1, ATF6, BiP, cyclin B2, OcaB (BOB1, Pou2af1). PMID: 25238757
11. Prostratin and HMBA, two well-studied activators of HIV transcription and latency, enhance ELL2 accumulation and SECs formation largely through decreasing Siah1 expression and ELL2 polyubiquitination. PMID: 22483617
12. ELL2 addition regulates mRNA processing by enhancing poly(A) site choice and exon splice-site skipping PMID: 19749764

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HGNC: 17064

OMIM: 601874

KEGG: hsa:22936

STRING: 9606.ENSP00000237853

UniGene: Hs.192221