ELMO2 Antibody

Datasheet

Code	CSB-PA836237LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA836237LA01HU at dilution of 1:100 Immunofluorescent analysis of A549 cells using CSB-PA836237LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) Western Blot Positive WB detected in: Mouse heart tissue All lanes: ELMO2 antibody at 3.4μg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 83, 73 kDa Observed band size: 83 kDa
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ELMO2 Polyclonal antibody

Uniprot No.

Q96JJ3

Target Names

ELMO2

Alternative Names

CED 12 antibody; Ced 12 homolog 2 antibody; CED 12 homolog A antibody; CED 12A antibody; CED-12 antibody; ced-12 homolog 2 antibody; CED12 antibody; CED12 homolog A antibody; CED12; C. elegans; homolog of; 2 antibody; CED12A antibody; ELMO 2 antibody; ELMO-2 antibody; ELMO2 antibody; ELMO2_HUMAN antibody; Engulfment and cell motility 2 (ced 12 homolog; C. elegans) antibody; Engulfment and cell motility 2 antibody; Engulfment and cell motility gene 2 antibody; Engulfment and cell motility protein 2 antibody; FLJ11656 antibody; hCED 12A antibody; hCED-12A antibody; hCED12A antibody; KIAA1834 antibody; OTTHUMP00000031762 antibody; PH domain protein CED12A antibody; Protein ced 12 homolog A antibody; Protein ced-12 homolog A antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Engulfment and cell motility protein 2 protein (304-371AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The ELMO2 Antibody (Product code: CSB-PA836237LA01HU) is Non-conjugated. For ELMO2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA836237LB01HU	ELMO2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA836237LC01HU	ELMO2 Antibody, FITC conjugated
Biotin	CSB-PA836237LD01HU	ELMO2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:200-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

Gene References into Functions

These data suggest a novel link between Tiam1 and RhoG/ILK /ELMO2 pathway as upstream effectors of the Rac1-mediated phagocytic process in trabecular meshwork cells. PMID: 27539661
studies demonstrate that Elmo2 is a new regulator of insulin-dependent Glut4 membrane translocation through modulating Rac1 activity and Akt membrane compartmentalization. PMID: 27226625
findings highlight the necessity of ELMO2 for maintaining vascular integrity, specifically in intramembranous bones; loss-of-function mutations in ELMO2 cause intraosseous vascular malformation by impeding RAC1 signaling PMID: 27476657
Axl has a role in phosphorylating the Elmo scaffold proteins to promote Rac activation and cell invasion PMID: 25332238
uncovered a role for ELMO in the recruitment of ACF7 to the membrane to promote microtubule capture and stability PMID: 23184944
Through its association with ELMO2, ILK plays key roles in the regulation of Rho GTPases and cross-talk pathways between adhesion and growth factor receptors. PMID: 22568984

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Involvement in disease

Vascular malformation, primary intraosseous (VMOS)

Subcellular Location

Cytoplasm. Cytoplasm, cytosol. Membrane.

Tissue Specificity

Widely expressed, with a higher expression in skeletal muscle, kidney and placenta.

Database Links

HGNC: 17233

OMIM: 606421

KEGG: hsa:63916

STRING: 9606.ENSP00000290246

UniGene: Hs.210469

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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