EMG1 Antibody

Datasheet

Code	CSB-PA007636GA01HU
Size	$600
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Product Details
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Target Background

Product Details

Uniprot No.

Q92979

Target Names

EMG1

Alternative Names

18S rRNA (pseudouridine(1248)-N1)-methyltransferase antibody; 18S rRNA Psi1248 methyltransferase antibody; C2F antibody; C2f protein antibody; EMG 1 antibody; EMG1 antibody; EMG1 N1 specific pseudouridine methyltransferase antibody; EMG1 nucleolar protein homolog (S cerevisiae) antibody; EMG1 nucleolar protein homolog antibody; essential for mitotic growth 1 antibody; FLJ60792 antibody; Grcc2f antibody; NEP1 antibody; NEP1_HUMAN antibody; Nucleolar protein EMG1 homolog antibody; Protein C2f antibody; Ribosomal RNA small subunit methyltransferase Nep1 antibody; Ribosome biogenesis protein NEP1 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human EMG1

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

S-adenosyl-L-methionine-dependent pseudouridine N(1)-methyltransferase that methylates pseudouridine at position 1248 (Psi1248) in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Is not able to methylate uridine at this position. Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-ribosomes.

Gene References into Functions

Our findings further indicate that in Bowen-Conradi syndrome, nuclear disassembly of the import complex and release of EMG1D86G lead to its nuclear aggregation and degradation, resulting in the reduced nucleolar recruitment of the RNA methyltransferase and defects in the biogenesis of the small ribosomal subunit. PMID: 27798105
Mutation of a gene essential for ribosome biogenesis, EMG1, causes Bowen-Conradi syndrome. PMID: 19463982

Involvement in disease

Bowen-Conradi syndrome (BWCNS)

Subcellular Location

Nucleus, nucleolus.

Protein Families

Class IV-like SAM-binding methyltransferase superfamily, RNA methyltransferase NEP1 family

Database Links

HGNC: 16912

OMIM: 211180

KEGG: hsa:10436

UniGene: Hs.558447

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Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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