EPRS Antibody, FITC conjugated

Code CSB-PA007747LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) EPRS Polyclonal antibody
Uniprot No.
Target Names
EPRS
Alternative Names
Bifunctional aminoacyl tRNA synthetase antibody; Bifunctional aminoacyl-tRNA synthetase antibody; Bifunctional glutamate/proline tRNA ligase antibody; Cell proliferation-inducing gene 32 protein antibody; DKFZp313B047 antibody; EARS antibody; Eprs antibody; GLNS antibody; Glu pro tRNA synthetase antibody; GLUPRORS antibody; GluRS antibody; Glutamate tRNA ligase antibody; Glutamatyl prolyl tRNA synthetase antibody; Glutaminyl tRNA synthetase antibody; Glutamyl prolyl tRNA synthetase antibody; Glutamyl tRNA synthetase antibody; Glutamyl-tRNA synthetase antibody; PARS antibody; PIG 32 antibody; PIG32 antibody; Proliferation inducing gene 32 protein antibody; Proliferation inducing protein 32 antibody; Proline tRNA ligase antibody; Proline--tRNA ligase antibody; Prolyl tRNA synthetase antibody; Prolyl-tRNA synthetase antibody; QARS antibody; QPRS antibody; SYEP_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Bifunctional glutamate/proline--tRNA ligase protein (1207-1399AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Multifunctional protein which is primarily part of the aminoacyl-tRNA synthetase multienzyme complex, also know as multisynthetase complex, that catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA. The phosphorylation of EPRS1, induced by interferon-gamma, dissociates the protein from the aminoacyl-tRNA synthetase multienzyme complex and recruits it to the GAIT complex that binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin), suppressing their translation. Interferon-gamma can therefore redirect, in specific cells, the EPRS1 function from protein synthesis to translation inhibition. Also functions as an effector of the mTORC1 signaling pathway by promoting, through SLC27A1, the uptake of long-chain fatty acid by adipocytes. Thereby, it also plays a role in fat metabolism and more indirectly influences lifespan.
Gene References into Functions
  1. five different EPRS mutations were identified. PMID: 29576217
  2. Data indicate the necessity of EPRS for proliferation of tamoxifen-resistant estrogen receptor (ER+) breast cancer, but not ER- breast cancer cells. PMID: 27612429
  3. analysis of the heterotetrameric complex structure of the glutathione transferase (GST) domains shared among the four MSC components, methionyl-tRNA synthetase (MRS), glutaminyl-prolyl-tRNA synthetase (EPRS), AIMP2 and AIMP3 PMID: 26472928
  4. Dynamic model simulations predicted an inhibitory GAIT-element-interacting factor to account for this relationship and led to the identification of a truncated form of EPRS, a GAIT constituent that mediates binding to target transcripts. PMID: 22386318
  5. Study reveals a unique role of Cdk5/p35 in activation of the major noncanonical function of EPRS, namely translational control of macrophage inflammatory gene expression. PMID: 21220307
  6. Results show that glutamyl-prolyl-tRNA synthetase has a regulated, noncanonical activity that blocks synthesis of a specific protein. PMID: 15479637
  7. Essentiality of this enzyme's domains in its noncanonical function of regulating inflammatory gene expression. PMID: 18374644
  8. EPRS phosphorylation events regulate GAIT-mediated gene silencing. PMID: 19647514

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Subcellular Location
Cytoplasm, cytosol. Membrane; Peripheral membrane protein.
Protein Families
Class-I aminoacyl-tRNA synthetase family, Glutamate--tRNA ligase type 2 subfamily; Class-II aminoacyl-tRNA synthetase family
Database Links

HGNC: 3418

OMIM: 138295

KEGG: hsa:2058

STRING: 9606.ENSP00000355890

UniGene: Hs.497788

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