ERI1 Antibody

Datasheet

Code	CSB-PA140707
Size	US$119
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q8IV48

Target Names

ERI1

Alternative Names

3' 5' exonuclease ERI 1 antibody; 3' 5' exonuclease ERI1 antibody; 3' EXO antibody; 3' exoribonuclease antibody; 3' HEXO antibody; 3' histone mRNA exonuclease 1 antibody; 3''-5'' exonuclease eri1 antibody; 3''-5'' exoribonuclease 1 antibody; 3'EXO antibody; 3'HEXO antibody; ERI 1 antibody; Eri 1 homolog antibody; Eri-1 homolog antibody; eri1 antibody; Eri1 homolog antibody; ERI1_HUMAN antibody; HEXO antibody; Histone mRNA 3' end specific exonuclease antibody; Histone mRNA 3' end specific exoribonuclease antibody; Histone mRNA 3''-end-specific exoribonuclease antibody; Histone mRNA 3''-exonuclease 1 antibody; MGC35395 antibody; Protein 3''hExo antibody; THEX 1 antibody; THEX1 antibody; Three prime histone mRNA exonuclease 1 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthesized peptide derived from the Internal region of Human ERI1.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

WB, ELISA

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:5000

Protocols

Western Blotting(WB) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.

Gene References into Functions

the crystal structure of a ternary complex of human SLBP RNA binding domain, human 3'hExo, and a 26-nucleotide stem-loop RNA is reported. PMID: 23329046
3'hExo is a primary candidate for the exonuclease that initiates rapid decay of histone mRNA upon completion and/or inhibition of DNA replication PMID: 14536070
molecular cloning; degrades siRNAs in vitro[ERI-1] PMID: 14961122
Data describe the structure of the nuclease domain of 3'-5'-exoribonuclease (3'hExo) complexed with rAMP in the presence of magnesium at 1.6 A resolution. PMID: 15451662
3'hExo is a 3' exonuclease specifically interacting with the 3' end of histone mRNA PMID: 16912046

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Subcellular Location

Cytoplasm. Nucleus. Nucleus, nucleolus.

Database Links

HGNC: 23994

OMIM: 608739

KEGG: hsa:90459

STRING: 9606.ENSP00000250263

UniGene: Hs.20000

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Phage Display Service

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Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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