ERP27 Antibody, HRP conjugated

Code CSB-PA842657LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ERP27 Polyclonal antibody
Uniprot No.
Target Names
ERP27
Alternative Names
C12orf46 antibody; Chromosome 12 open reading frame 46 antibody; Endoplasmic reticulum protein 27 antibody; Endoplasmic reticulum protein 27 kDa antibody; Endoplasmic reticulum resident protein 27 antibody; Endoplasmic reticulum resident protein ERp27 antibody; ER protein 27 antibody; ERp 27 antibody; ERp27 antibody; ERP27_HUMAN antibody; FLJ32115 antibody; PDIA8 antibody; Protein disulfide isomerase family A; member 8 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Endoplasmic reticulum resident protein 27 protein (26-273AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Specifically binds unfolded proteins and may recruit protein disulfide isomerase PDIA3 to unfolded substrates. Binds protein substrates via a hydrophobic pocket in the C-terminal domain. May play a role in the unfolded stress response.
Gene References into Functions
  1. High-resolution NMR studies of structure and dynamics of human ERp27 indicate extensive interdomain flexibility PMID: 23234573
  2. ERp27 is able to distinguish between folded and unfolded substrates, only interacting with the latter and presenting them to for catalysis. PMID: 23192347
  3. ERp27 is bound by ERp57 both in vitro and in vivo by a similar mechanism by which ERp57 binds calreticulin PMID: 16940051
Subcellular Location
Endoplasmic reticulum lumen.
Protein Families
Protein disulfide isomerase family
Database Links

HGNC: 26495

OMIM: 610642

KEGG: hsa:121506

STRING: 9606.ENSP00000266397

UniGene: Hs.162143

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