ESPN Antibody

1. A significant inverse correlation was observed between miR-612 and Espin protein expression in melanoma tissues. PMID: 29385671
2. The utricles were then treated with a gamma-secretase inhibitor, followed by espin or control transduction and histochemistry. Although gamma-secretase inhibition increased the number of HCs, few had stereociliary arrays. In contrast, 46 h after espin1 transduction, a significant increase in hair-bundle-like structures was observed PMID: 26886463
3. The espin actin-filament-binding site has a major effect on the formation and dynamics of actin bundles. PMID: 24424026
4. human deafness and vestibular dysfunction co-segregated with either of two frameshift mutations in ESPN. PMID: 15286153
5. The results further strengthen the causative role of the espin gene in non-syndromic hearing loss and add new insights into espin structure and function. PMID: 15930085
6. Here, we report a new activity of the espins, one that depends on their enigmatic WH2 domain: the ability to assemble a large actin bundle when targeted to a specific subcellular location. PMID: 16569662
7. A recessive ESPN mutation causing congenital hearing loss in a Morocan family was reported. PMID: 18973245
8. Flies with mutations affecting the diaphanous,forked, and CG12026/TMHS genes displayed significant reductions in the amplitude of sound-evoked potentials compared to wild-type flies PMID: 19102128

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HGNC: 13281

OMIM: 606351

KEGG: hsa:83715

STRING: 9606.ENSP00000367059

UniGene: Hs.744222