ESRRG Antibody

Code CSB-PA034482
Size US$166
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Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using CSB-PA034482(ESRRG Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA034482(ESRRG Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
  • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse lung tissue, Primary antibody: CSB-PA034482(ESRRG Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds
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Product Details

Uniprot No.
Target Names
ESRRG
Alternative Names
DKFZp781L1617 antibody; ERR 3 antibody; ERR G2 antibody; ERR gamma 2 antibody; ERR gamma-2 antibody; ERR3 antibody; ERR3_HUMAN antibody; ERRG 2 antibody; ERRG2 antibody; ERRgamma antibody; ESRRG antibody; Estrogen receptor related protein 3 antibody; Estrogen receptor-related protein 3 antibody; Estrogen-related receptor gamma antibody; FLJ16023 antibody; KIAA0832 antibody; NR3B3 antibody; Nuclear receptor subfamily 3 group B member 3 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Fusion protein of Human ESRRG
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Tested Applications
ELISA,WB,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:2000-1:5000
WB 1:500-1:2000
IHC 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function
Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements. Induces the expression of PERM1 in the skeletal muscle.
Gene References into Functions
  1. ERRgamma may exert oncogenic activity mainly associated with aggressiveness of EC by activating S100A4 transcription. PMID: 29901152
  2. Loss of ERRgamma in renal epithelial cells Results in Kidney Disease with Cysts. PMID: 29735694
  3. our present results show an intriguing association between the ESRRG rs1890552 GG genotype and an increased risk of impaired fasting glucose or type 2 diabetes mellitus as well as increased oxidative stress. PMID: 28034514
  4. It was also associated with beta-cell function (P=1.99 x 10(-3)) and fasting glucose level (P<0.05) in the meta-analyses of glucose and insulin-related traits consortium (MAGIC) data set.Cnoclusions:In summary, we identified epigenomic characteristics for obesity genes and suggested ESRRG as a novel obesity-susceptibility gene PMID: 27113491
  5. this study elucidates a molecular mechanism linking CB1R signaling, ERRgamma expression and fibrinogen gene transcription. PMID: 28750085
  6. Disruption of the orphan receptor ESRRG and disruption of KIAA0825 identified in a subject with hearing loss and mild developmental delay. Given the translocation breakpoints and supporting literature, disruption of ESRRG is the most likely cause for the disorder. PMID: 27381092
  7. Data suggest that activation of ERRgamma is involved in induction of matrix metalloproteinases 2/9 (MMP2 and MMP9) and increased migration/invasiveness of triple-negative breast cancer cells caused by low concentrations of environmental endocrine disruptors (nanomolar bisphenol A used here). PMID: 27038254
  8. The present results strongly suggest that human nuclear receptor ERRgamma functions as a genuine homomeric dimer with symmetrical dimeric interface regions. PMID: 26662629
  9. ERRgamma overexpression directs metabolic maturation in human Induced Pluripotent Stem Cells-derived beta-like cells. PMID: 27076077
  10. Estrogen-related receptor gamma is upregulated in liver cancer and its inhibition suppresses liver cancer cell proliferation via induction of p21 and p27. PMID: 26940882
  11. Data show that micrRNA miR-320a directly targets cAMP-regulated phosphoprotein 19 (ARPP-19) and estrogen-related receptor gamma protein (ERRgamma) in breast cancer cell lines. PMID: 25736597
  12. ERRgamma signaling is associated with poor DMFS in ER+, TAM-treated breast cancer PMID: 25971350
  13. ESRRG is down-regulated in placenta from intrauterine growth restriction tissue. PMID: 26051094
  14. Results suggest that hypoxia-inducible factor-1alpha can positively regulate the dopaminergic phenotype through estrogen-related receptor gamma . PMID: 25807177
  15. The results reveal that the double-layer binding sites, namely, the ordinary ligand binding sites and their back support residues, substantiate the strong binding of BPA to ERRgamma. PMID: 24978476
  16. A role for ESRRG in maternal blood pressure homeostasis during pregnancy. PMID: 24725083
  17. Report estrogen-mediated cell kinetics and the role of oestrogen-related receptor gamma on biliary epithelial cells in the pathogenesis of primary biliary cirrhosis. PMID: 24687322
  18. ERRgamma protein levels are affected by the activation state of ERK/mitogen-activated protein kinase, and mutation of consensus ERK target sites impairs ERRgamma-driven transcriptional activity and tamoxifen resistance. PMID: 24684682
  19. These findings demonstrate a novel ERRgamma/GATA4 signal cascade in the development of cardiac hypertrophy. PMID: 24083978
  20. Nuclear ANG directly binds to the ANG-Binding Sequence within ERRgamma of ERRgamma gene and inhibits ERRgamma transcription to promote breast cancer cell proliferation. PMID: 23977052
  21. ERRGamma mediates oxygen-dependent expression of genes involved in human trophoblast differentiation, function, and vascular homeostasis. PMID: 23584901
  22. Iranian women with short AAAG repeat are at higher risk of breast cancer. PMID: 24125170
  23. plays a role in maintenance of hearing in both humans and mice. PMID: 23540940
  24. The ESRRG gene is a novel target of miR-205 mediated RNA-interference. PMID: 23589079
  25. Data show that the orphan nuclear receptor estrogen related receptor gamma (ERRgamma) plays a critical role in hypoxia-mediated activation of pyruvate dehydrogenase kinase 4 (PDK4) gene expression. PMID: 23050013
  26. results suggest that Estrogen-Related Receptor gamma (ERRgamma) could be implicated in the energy metabolism regulation of human trophoblasts PMID: 22763271
  27. Orphan nuclear receptor estrogen-related receptor gamma (ERRgamma) is key regulator of hepatic gluconeogenesis PMID: 22549789
  28. Our study indicates that the AAAG tetranucleotide repeat polymorphism in ERR-gamma gene 5' UTR region may be a new biomarker for genetic susceptibility to breast cancer. PMID: 21153485
  29. Disorder-to-order transition underlies the structural basis for the assembly of a transcriptionally active PGC-1alpha/ERRgamma complex PMID: 22049338
  30. Estrogen-related receptor gamma (ERRgamma) is a novel transcriptional regulator of phosphatidic acid phosphatase, LIPIN1, and inhibits hepatic insulin signaling PMID: 21911493
  31. These novel findings identify ERRgamma as an O(2)-dependent transcription factor and HIF-1alpha target gene that serves a critical role in the induction of hCYP19 expression during human trophoblast differentiation. PMID: 21757507
  32. Study provides evidence for nuclear receptor mediated regulation of Dnmt1 expression through ERRgamma and SHP crosstalk. PMID: 21459093
  33. miR-378( *) inhibits the expression of two PGC-1beta partners, ERRgamma and GABPA, leading to a reduction in TCA cycle gene expression and oxygen consumption as well as an increase in lactate production and in cell proliferation PMID: 20889127
  34. Estrogen-related receptor gamma modulates cell proliferation and estrogen signaling in breast cancer. PMID: 20883782
  35. These results suggest involvement of ESRRgamma in the determination of bone density in women. PMID: 19821770
  36. Transcriptional activation by ERR3 can be ligand-independent. PMID: 11864604
  37. Not only PNRC2 but also the corepressor TLE1 functioned as ERRgamma coactivator in a reporter gene analysis PMID: 14651967
  38. Up-regulation of estrogen-related receptor gamma is associated with endometrial adenocarcinoma PMID: 16681769
  39. Thermal stability studies show that agonist binding leads to global stabilization of the ligand binding domain. PMID: 16990259
  40. is a novel target of ERRgamma, and their interaction is crucial for cancer cell proliferation PMID: 17706602
  41. First evidence is provided that the nuclear receptor estrogen-related receptor gamma forms complexes with the endocrine disruptor, providing detailed molecular insight into the interaction features. PMID: 17761695
  42. Results clearly indicate that estrogen-related receptor gamma forms an appropriate structure presumably to adopt an unidentified endogenous ligand. PMID: 18005256
  43. ERRGamma (estrogen-related receptor gamma ) mRNA levels decreased from normal vagina of the pre-menopausal women to atrophic vaginal tissue in post-menopausal women PMID: 18328649
  44. The 2.0 A crystal structure of the 4-alpha-cumylphenol/ERRgamma complex clearly revealed that ERRgamma's Leu345-beta-isopropyl plays a role in the tight binding of 4-alpha-cumylphenol and BPA, rotating in a back-and-forth induced-fit manner. PMID: 18582436
  45. Kaempferol is an estrogen-related receptor gamma inverse agonist. PMID: 19171140
  46. placenta expresses ERRgamma mRNA extremely highly; among the 3 ERRgamma protein isoforms, placenta exclusively expresses the type-1 isoform; results suggest that bisphenol A accumulates in the placenta by binding to ERRgamma PMID: 19304792
  47. Single nucleotide polymorphisms in the estrogen-related receptor gamma is Associated with post-menopausal breast cancer women. PMID: 19415745
  48. SMILE is a novel corepressor of ERRgamma, and SIRT1 has a role as a novel repressive mechanism for SMILE and ERRgamma inverse agonist PMID: 19690166

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Subcellular Location
Nucleus.
Protein Families
Nuclear hormone receptor family, NR3 subfamily
Tissue Specificity
Expressed in the heart, kidney, brain, lung, bone marrow, adrenal gland, trachea, spinal cord and thyroid gland.
Database Links

HGNC: 3474

OMIM: 602969

KEGG: hsa:2104

STRING: 9606.ENSP00000386171

UniGene: Hs.444225

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