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Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements. Induces the expression of PERM1 in the skeletal muscle.
Gene References into Functions
ERRgamma may exert oncogenic activity mainly associated with aggressiveness of EC by activating S100A4 transcription. PMID: 29901152
Loss of ERRgamma in renal epithelial cells Results in Kidney Disease with Cysts. PMID: 29735694
our present results show an intriguing association between the ESRRG rs1890552 GG genotype and an increased risk of impaired fasting glucose or type 2 diabetes mellitus as well as increased oxidative stress. PMID: 28034514
It was also associated with beta-cell function (P=1.99 x 10(-3)) and fasting glucose level (P<0.05) in the meta-analyses of glucose and insulin-related traits consortium (MAGIC) data set.Cnoclusions:In summary, we identified epigenomic characteristics for obesity genes and suggested ESRRG as a novel obesity-susceptibility gene PMID: 27113491
this study elucidates a molecular mechanism linking CB1R signaling, ERRgamma expression and fibrinogen gene transcription. PMID: 28750085
Disruption of the orphan receptor ESRRG and disruption of KIAA0825 identified in a subject with hearing loss and mild developmental delay. Given the translocation breakpoints and supporting literature, disruption of ESRRG is the most likely cause for the disorder. PMID: 27381092
Data suggest that activation of ERRgamma is involved in induction of matrix metalloproteinases 2/9 (MMP2 and MMP9) and increased migration/invasiveness of triple-negative breast cancer cells caused by low concentrations of environmental endocrine disruptors (nanomolar bisphenol A used here). PMID: 27038254
The present results strongly suggest that human nuclear receptor ERRgamma functions as a genuine homomeric dimer with symmetrical dimeric interface regions. PMID: 26662629
ERRgamma overexpression directs metabolic maturation in human Induced Pluripotent Stem Cells-derived beta-like cells. PMID: 27076077
Estrogen-related receptor gamma is upregulated in liver cancer and its inhibition suppresses liver cancer cell proliferation via induction of p21 and p27. PMID: 26940882
Data show that micrRNA miR-320a directly targets cAMP-regulated phosphoprotein 19 (ARPP-19) and estrogen-related receptor gamma protein (ERRgamma) in breast cancer cell lines. PMID: 25736597
ERRgamma signaling is associated with poor DMFS in ER+, TAM-treated breast cancer PMID: 25971350
ESRRG is down-regulated in placenta from intrauterine growth restriction tissue. PMID: 26051094
Results suggest that hypoxia-inducible factor-1alpha can positively regulate the dopaminergic phenotype through estrogen-related receptor gamma . PMID: 25807177
The results reveal that the double-layer binding sites, namely, the ordinary ligand binding sites and their back support residues, substantiate the strong binding of BPA to ERRgamma. PMID: 24978476
A role for ESRRG in maternal blood pressure homeostasis during pregnancy. PMID: 24725083
Report estrogen-mediated cell kinetics and the role of oestrogen-related receptor gamma on biliary epithelial cells in the pathogenesis of primary biliary cirrhosis. PMID: 24687322
ERRgamma protein levels are affected by the activation state of ERK/mitogen-activated protein kinase, and mutation of consensus ERK target sites impairs ERRgamma-driven transcriptional activity and tamoxifen resistance. PMID: 24684682
These findings demonstrate a novel ERRgamma/GATA4 signal cascade in the development of cardiac hypertrophy. PMID: 24083978
Nuclear ANG directly binds to the ANG-Binding Sequence within ERRgamma of ERRgamma gene and inhibits ERRgamma transcription to promote breast cancer cell proliferation. PMID: 23977052
ERRGamma mediates oxygen-dependent expression of genes involved in human trophoblast differentiation, function, and vascular homeostasis. PMID: 23584901
Iranian women with short AAAG repeat are at higher risk of breast cancer. PMID: 24125170
plays a role in maintenance of hearing in both humans and mice. PMID: 23540940
The ESRRG gene is a novel target of miR-205 mediated RNA-interference. PMID: 23589079
Data show that the orphan nuclear receptor estrogen related receptor gamma (ERRgamma) plays a critical role in hypoxia-mediated activation of pyruvate dehydrogenase kinase 4 (PDK4) gene expression. PMID: 23050013
results suggest that Estrogen-Related Receptor gamma (ERRgamma) could be implicated in the energy metabolism regulation of human trophoblasts PMID: 22763271
Orphan nuclear receptor estrogen-related receptor gamma (ERRgamma) is key regulator of hepatic gluconeogenesis PMID: 22549789
Our study indicates that the AAAG tetranucleotide repeat polymorphism in ERR-gamma gene 5' UTR region may be a new biomarker for genetic susceptibility to breast cancer. PMID: 21153485
Disorder-to-order transition underlies the structural basis for the assembly of a transcriptionally active PGC-1alpha/ERRgamma complex PMID: 22049338
Estrogen-related receptor gamma (ERRgamma) is a novel transcriptional regulator of phosphatidic acid phosphatase, LIPIN1, and inhibits hepatic insulin signaling PMID: 21911493
These novel findings identify ERRgamma as an O(2)-dependent transcription factor and HIF-1alpha target gene that serves a critical role in the induction of hCYP19 expression during human trophoblast differentiation. PMID: 21757507
Study provides evidence for nuclear receptor mediated regulation of Dnmt1 expression through ERRgamma and SHP crosstalk. PMID: 21459093
miR-378( *) inhibits the expression of two PGC-1beta partners, ERRgamma and GABPA, leading to a reduction in TCA cycle gene expression and oxygen consumption as well as an increase in lactate production and in cell proliferation PMID: 20889127
Estrogen-related receptor gamma modulates cell proliferation and estrogen signaling in breast cancer. PMID: 20883782
These results suggest involvement of ESRRgamma in the determination of bone density in women. PMID: 19821770
Transcriptional activation by ERR3 can be ligand-independent. PMID: 11864604
Not only PNRC2 but also the corepressor TLE1 functioned as ERRgamma coactivator in a reporter gene analysis PMID: 14651967
Up-regulation of estrogen-related receptor gamma is associated with endometrial adenocarcinoma PMID: 16681769
Thermal stability studies show that agonist binding leads to global stabilization of the ligand binding domain. PMID: 16990259
is a novel target of ERRgamma, and their interaction is crucial for cancer cell proliferation PMID: 17706602
First evidence is provided that the nuclear receptor estrogen-related receptor gamma forms complexes with the endocrine disruptor, providing detailed molecular insight into the interaction features. PMID: 17761695
Results clearly indicate that estrogen-related receptor gamma forms an appropriate structure presumably to adopt an unidentified endogenous ligand. PMID: 18005256
ERRGamma (estrogen-related receptor gamma ) mRNA levels decreased from normal vagina of the pre-menopausal women to atrophic vaginal tissue in post-menopausal women PMID: 18328649
The 2.0 A crystal structure of the 4-alpha-cumylphenol/ERRgamma complex clearly revealed that ERRgamma's Leu345-beta-isopropyl plays a role in the tight binding of 4-alpha-cumylphenol and BPA, rotating in a back-and-forth induced-fit manner. PMID: 18582436
Kaempferol is an estrogen-related receptor gamma inverse agonist. PMID: 19171140
placenta expresses ERRgamma mRNA extremely highly; among the 3 ERRgamma protein isoforms, placenta exclusively expresses the type-1 isoform; results suggest that bisphenol A accumulates in the placenta by binding to ERRgamma PMID: 19304792
Single nucleotide polymorphisms in the estrogen-related receptor gamma is Associated with post-menopausal breast cancer women. PMID: 19415745
SMILE is a novel corepressor of ERRgamma, and SIRT1 has a role as a novel repressive mechanism for SMILE and ERRgamma inverse agonist PMID: 19690166
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Subcellular Location
Nucleus.
Protein Families
Nuclear hormone receptor family, NR3 subfamily
Tissue Specificity
Expressed in the heart, kidney, brain, lung, bone marrow, adrenal gland, trachea, spinal cord and thyroid gland.