EVL Antibody

Code CSB-PA007869GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
EVL
Alternative Names
EVL antibody; RNB6Ena/VASP-like protein antibody; Ena/vasodilator-stimulated phosphoprotein-like antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human EVL
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization.
Gene References into Functions
  1. EVL/miR-342 methylation was preferentially detected in IgD multiple myeloma PMID: 29242101
  2. Identify CRMP-1 as a novel regulator of actin filament elongation and reveal a surprisingly important role for CRMP-1, EVL, and actin polymerization in maintaining the structural integrity of epithelial sheets. PMID: 28630144
  3. ENA/VASP-family proteins are functionally redundant in homologous recombination, and MENA, VASP and EVL may be involved in the DSB repair pathway in humans PMID: 21398369
  4. EVL, with either E. coli topoisomerase I or human topoisomerase IIIalpha, catalyzed ssDNA catenation. PMID: 20639531
  5. Ena/VASP proteins regulate actin polymerization at actin filament barbed ends in vitro in the presence and absence of barbed end capping proteins. PMID: 15939738
  6. the interaction of the alphaII-spectrin SH3 domain with EVL PMID: 16336193
  7. Data suggest that ena/VASP binding to F-actin allows for gephyrin recruitment to the leading edge of uncapped actin filaments. PMID: 16376568
  8. EVL is required for endothelial barrier function in vivo. PMID: 17998398
  9. A microRNA encoded in an intron of the gene EVL, is commonly suppressed in human colorectal cancer. PMID: 18264139
  10. EVL may be implicated in invasion and/or metastasis of human breast cancer. PMID: 18357390
  11. EVL protein is a novel recombination factor that may be required for repairing specific DNA lesions, and that may cause tumor malignancy by its inappropriate expression. PMID: 19329439
  12. EVH2 domain, which is highly conserved among the ENA/VASP family proteins, may be responsible for the recombination function of EVL. PMID: 19725871

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Subcellular Location
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, stress fiber. Cell projection, lamellipodium.
Protein Families
Ena/VASP family
Database Links

HGNC: 20234

KEGG: hsa:51466

STRING: 9606.ENSP00000376652

UniGene: Hs.125867

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