EXOC4 Antibody

1. Sec8 regulates N-cadherin expression by controlling Smad3 and Smad4 expression through CBP, thereby mediating the epithelial-mesenchymal transition. PMID: 27769780
2. Sec8 regulate Bcl-2 and Mcl-1 expressions but not Bcl-xl in malignant peripheral nerve sheath tumor cells. PMID: 26892009
3. Sec8 regulates histone-modifying proteins ATF2 and RNF20. PMID: 26283729
4. Sec8 knockdown in HSC3 cells resulted in reduced expressions of PAK1 and PAK2 by upregulating Pirh2 and Siah1 expression, which inhibited the ERK or p38 MAPK signalling pathway and cytokeratin8 phosphorylation and cell migration. PMID: 25725287
5. knockdown of Sec8 enhances the binding of JIP4 to MAPK kinase 4, thereby decreasing the phosphorylation of MAPK kinase 4, JNK, and p38. PMID: 25244576
6. Exome sequencing revealed a likely pathogenic mutation in three novel candidate MKS disease genes-C5orf42, EVC2 and SEC8 (also known as EXOC4), which encodes an exocyst protein with an established role in ciliogenesis PMID: 23169490
7. High Sec8 expression is associated with progression of oral squamous-cell carcinoma by secretion of matrix metalloproteinases. PMID: 23207790
8. EXOC4 is involved in insulin-stimulated glucose transport and may be a candidate for an association with type 2 diabetes. PMID: 18498660

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HGNC: 30389

OMIM: 608185

KEGG: hsa:60412

STRING: 9606.ENSP00000253861

UniGene: Hs.321273