EXOSC1 Antibody

Code CSB-PA007888GA01HU
Size US$685
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Product Details

Uniprot No. Q9Y3B2
Target Names EXOSC1
Alternative Names 3'-5' exoribonuclease CSL4 homolog antibody; CGI 108 antibody; CGI-108 antibody; CSL4 antibody; CSL4 exosomal core protein homolog antibody; CSL4, S. cerevisiae, homolog of antibody; Csl4p antibody; EXOS1_HUMAN antibody; Exosc1 antibody; Exosomal core protein CSL4 antibody; Exosome complex component csl4 antibody; Exosome component 1 antibody; hCsl4p antibody; Homolog of yeast exosomal core protein CSL4 antibody; p13 antibody; RP11-452K12.9 antibody; SKI4 antibody; Ski4p antibody
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen Human EXOSC1
Immunogen Species Homo sapiens (Human)
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications ELISA,WB,IHC
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC1 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC6 and EXOSC8.
Gene References into Functions
  1. The combined p16- and p53-expression status in cervical metastases of CUP may represent a simple method for risk stratification. Further validation of these biomarkers in large prospective trials is essential to design rational trials for CUP treatment optimization. PMID: 28144684
  2. Human exosome hCsl4p participates in RNA degradation. PMID: 22068837
  3. association of hCsl4p with the exosome is mediated by protein-protein interactions with hRrp42p and hRrp46p PMID: 11812149
Subcellular Location Nucleus, nucleolus, Nucleus, Cytoplasm
Protein Families CSL4 family
Database Links

HGNC: 17286

OMIM: 606493

KEGG: hsa:51013

STRING: 9606.ENSP00000359939

UniGene: Hs.632089


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