FAF2 Antibody

1. We present physiological evidence that UBXN3B positively regulates stimulator-of-interferon genes (STING) signaling. Mechanistic studies demonstrate that UBXN3B interacts with both STING and its E3 ligase TRIM56, and facilitates STING ubiquitination, dimerization, trafficking, and consequent recruitment and phosphorylation of TBK1. PMID: 29899553
2. UBXD8 is necessary for sterol-stimulated dislocation of ubiquitylated HMGCR from the endoplasmic reticulum membrane en route to proteasomal degradation, a function dependent on its UBX domain. PMID: 28882874
3. that newly synthesized UBXD8 is post-translationally inserted into discrete ER subdomains by a mechanism requiring cytosolic PEX19 and membrane-integrated PEX3, proteins hitherto exclusively implicated in peroxisome biogenesis PMID: 27295553
4. role of UBXD8 in cellular responses to excess fatty acids PMID: 24378746
5. the UAS domain of Ubxd8 mediates it's polymerization upon interaction with long-chain unsaturated fatty acids PMID: 23720822
6. UBXD8-mediated recruitment of p97/VCP to LDs increases lipid droplet (LD) size by inhibiting the activity of adipose triglyceride lipase (ATGL), the rate-limiting enzyme in triacylglycerol hydrolysis. PMID: 23297223
7. Ubx2 and Ubxd8 regulates lipid droplet homeostasis. PMID: 22454508
8. These results indicate that ApoB after lipidation is dislocated from the ER lumen to the LD surface for proteasomal degradation and that Derlin-1 and UBXD8 are engaged in the predislocation and postdislocation steps, respectively. PMID: 22238364
9. These results suggest that Ubxd8 acts as a brake that limits triglyceride synthesis, and this brake is released when its structure is altered by exposure to unsaturated fatty acids. PMID: 21115839
10. These findings provide evidence for conserved ubiquitination pathways regulating the RasGAP proteins Ira2 (in yeast) and neurofibromin (in humans). PMID: 20160012
11. ETEA may play a role in the regulating the resistance to apoptosis that is observed in T cells and eosinophils of AD patients PMID: 12372427

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HGNC: 24666

OMIM: 616935

KEGG: hsa:23197

STRING: 9606.ENSP00000261942

UniGene: Hs.484242