FAM111A Antibody

Datasheet

Code	CSB-PA853484LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA853484LA01HU at dilution of 1:100 Immunofluorescent analysis of HepG2 cells using CSB-PA853484LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) FAM111A Polyclonal antibody

Uniprot No.

Q96PZ2

Target Names

FAM111A

Alternative Names

FAM111A antibody; KIAA1895Protein FAM111A antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Protein FAM111A protein (26-179AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The FAM111A Antibody (Product code: CSB-PA853484LA01HU) is Non-conjugated. For FAM111A Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA853484LB01HU	FAM111A Antibody, HRP conjugated	ELISA
FITC	CSB-PA853484LC01HU	FAM111A Antibody, FITC conjugated
Biotin	CSB-PA853484LD01HU	FAM111A Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Single-stranded DNA-binding serine protease that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a key role in maintaining genomic integrity. DPCs are highly toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription, and which are induced by reactive agents, such as UV light or formaldehyde. Protects replication fork from stalling by removing DPCs, such as covalently trapped topoisomerase 1 (TOP1) adducts on DNA lesion, or poly(ADP-ribose) polymerase 1 (PARP1)-DNA complexes trapped by PARP inhibitors. Required for PCNA loading on replication sites. Promotes S-phase entry and DNA synthesis.; (Microbial infection) May directly function at replication forks, explaining why Simian virus 40 (SV40) interacts with FAM111A to overcome host range restriction.

Gene References into Functions

Together, these data suggest that FAM111A may also be important in the development and function of male genitalia. 394 PMID: 24635597
study would provide evidence that FAM111A is a key molecule for normal bone development, height gain, and parathyroid hormone development and/or regulation PMID: 23996431
FAM111A is a replication factor required for PCNA loading. PMID: 24561620
FAM111A appears to be crucial to a pathway that governs parathyroid hormone production, calcium homeostasis, and skeletal development and growth. PMID: 23684011
FAM111A functions as a host range restriction factor that is specifically targeted by SV40 large T antigen PMID: 23093934

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Involvement in disease

Kenny-Caffey syndrome 2 (KCS2); Gracile bone dysplasia (GCLEB)

Subcellular Location

Nucleus. Chromosome. Cytoplasm.

Protein Families

FAM111 family

Database Links

HGNC: 24725

OMIM: 127000

KEGG: hsa:63901

UniGene: Hs.150651

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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